\u4eca\u65e5\u306f\u4e73\u304c\u3093\u306b\u95a2\u3059\u308b\u30e1\u30eb\u30de\u30ac\u304b\u3089<\/p>\n
\u6c17\u306b\u306a\u3063\u305f\u5b66\u4f1a\u30ec\u30dd\u30fc\u30c8\u3092\u8ee2\u8f09\u3057\u307e\u3059\u3002
\n\u51fa\u5178\uff1a\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30ebOncology\u30ea\u30dd\u30fc\u30c8
\n\u8457\uff1a\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc<\/p>\n
<\/p>\n
\u4e73\u764c\u306e\u5316\u5b66\u7642\u6cd5\u3067\u3055\u3089\u306a\u308b\u500b\u5225\u5316\u3092\u76ee\u6307\u3059\u53d6\u308a\u7d44\u307f\u9032\u3080<\/strong><\/p>\n <\/p>\n \u4e73\u764c\u306b\u5bfe\u3059\u308b\u5316\u5b66\u7642\u6cd5\u306f\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u9069\u3057\u305f\u6cbb\u7642\u306e\u63d0\u4f9b\u304c<\/p>\n \u3088\u308a\u91cd\u8996\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u5b9f\u73fe\u306b\u5411\u3051\u3055\u307e\u3056\u307e\u306a\u53d6\u308a\u7d44\u307f\u304c<\/p>\n \u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n pCR\uff08\u75c5\u7406\u5b66\u7684\u5b8c\u5168\u594f\u52b9\uff09\u3092\u76ee\u6a19\u306b\u3057\u305f\u521d\u767a\u4e73\u764c\u306b\u5bfe\u3059\u308b<\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u3001\u518d\u767a\u6291\u5236\u3092\u76ee\u6a19\u3068\u3057\u305f\u8853\u5f8c\u5316\u5b66\u7642\u6cd5\u3001\u4e88\u5f8c\u6539\u5584\u3084<\/p>\n QOL\u306e\u6539\u5584\u3092\u76ee\u6a19\u3068\u3057\u305f\u518d\u767a\u4e73\u764c\u306e\u305d\u308c\u305e\u308c\u306b\u304a\u3044\u3066\u3001<\/p>\n \u500b\u3005\u306e\u60a3\u8005\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\u5f37\u5ea6\u3084\u85ac\u5264\u306e\u5909\u66f4\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n <\/p>\n \u798f\u5ca1\u5e02\u30677\u6708\u306b\u958b\u50ac\u3055\u308c\u305f\u7b2c25\u56de\u65e5\u672c\u4e73\u764c\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\u306e\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/p>\n \u300c\u521d\u767a\u30fb\u518d\u767a\u4e73\u764c\u306b\u5bfe\u3059\u308b\u5316\u5b66\u7642\u6cd5\uff08\u5358\u72ec\u304a\u3088\u3073\u4f75\u7528\u7642\u6cd5\uff09\u306e\u65b0\u305f\u306a\u5c55\u958b\u300d<\/p>\n \uff08\u5ea7\u9577\uff1a\u304f\u307e\u3082\u3068\u68ee\u90fd\u7dcf\u5408\u75c5\u9662\u4e73\u817a\u30bb\u30f3\u30bf\u30fc\u30fb\u897f\u6751\u4ee4\u559c\u6c0f\u3001<\/p>\n \u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u4e73\u817a\u5916\u79d1\u5b66\u5206\u91ce\u30fb\u9060\u5c71\u7adc\u4e5f\u6c0f\uff09<\/p>\n \u3067\u306f\u3001\u3053\u3046\u3057\u305f\u53d6\u308a\u7d44\u307f\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3055\u308c\u305f\u3002<\/p>\n \u65e5\u672c\u767a\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u4e2d\u5fc3\u306b\u3001\u521d\u767a\u4e73\u764c\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e<\/p>\n \u65b0\u305f\u306a\u52d5\u5411\u304c\u7d39\u4ecb\u3055\u308c\u3001\u307e\u305f\u518d\u767a\u4e73\u764c\u3067\u306fQOL\u306e\u7dad\u6301\u306b\u914d\u616e\u3057\u306a\u304c\u3089<\/p>\n \u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u3092\u76ee\u6307\u3059\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u3044\u3066\u5831\u544a\u3055\u308c\u305f\u3002<\/p>\n <\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u304c\u500b\u5225\u5316\u6cbb\u7642\u306e\u790e\u306e1\u3064\u306b<\/b><\/p>\n <\/p>\n \u56fd\u7acb\u75c5\u9662\u6a5f\u69cb\u5927\u962a\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u4e73\u817a\u5916\u79d1\u306e\u5897\u7530\u614e\u4e09\u6c0f\u306f\u3001<\/p>\n \u65e5\u672c\u3068\u97d3\u56fd\u304c\u5171\u540c\u3067\u884c\u3063\u305fCREATE-X\u8a66\u9a13\u306e\u7d50\u679c\u3092\u4e2d\u5fc3\u306b\u89e3\u8aac\u3057\u3001<\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u6cbb\u7642\u53cd\u5fdc\u6027\u3092\u6307\u6a19\u3068\u3057\u3066\u3001\u8853\u5f8c\u306e\u85ac\u5264\u3084\u6cbb\u7642\u5f37\u5ea6\u3092<\/p>\n \u5909\u66f4\u3059\u308b\u3053\u3068\u304c\u4e88\u5f8c\u306e\u6539\u5584\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u3002<\/p>\n <\/p>\n \u4e73\u764c\u306e\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3067\u306f\u3001\u3088\u308a\u9ad8\u3044pCR\u7387\u304c\u671f\u5f85\u3067\u304d\u308b<\/p>\n \u30ec\u30b8\u30e1\u30f3\u306e\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u304d\u305f\u3002<\/p>\n \u4e00\u65b9\u3067\u3001pCR\u304c\u5f97\u3089\u308c\u306a\u3044\u4e88\u5f8c\u4e0d\u826f\u306e\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3082\u8ab2\u984c\u3068\u3055\u308c\u3001<\/p>\n JBCRG\uff08Japan Breast Cancer Research Group\uff09\u304c\u53d6\u308a\u7d44\u3093\u3060\u306e\u304c<\/p>\n CREATE-X\u8a66\u9a13\u3060\u3063\u305f\u3002\u540c\u8a66\u9a13\u306f\u3001\u4e2d\u9593\u89e3\u6790\u3067\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u9054\u6210\u3057\u305f\u3053\u3068\u304c<\/p>\n \u660e\u3089\u304b\u306b\u306a\u308a\u3001\u65e9\u671f\u4e2d\u6b62\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n \uff08N. Masuda, et al. N Engl J Med 2017\uff1b376\uff1a2147-59\uff09<\/p>\n <\/p>\n \u5bfe\u8c61\u306f\u3001HER2\u9670\u6027\u4e73\u764c\u3067\u3001\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3068\u3057\u3066\u30a2\u30f3\u30b9\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u3001<\/p>\n \u30bf\u30ad\u30b5\u30f3\u3001\u307e\u305f\u306f\u4e21\u65b9\u304c\u6295\u4e0e\u3055\u308c\u3001pCR\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u60a3\u8005\u3001<\/p>\n \u3082\u3057\u304f\u306fpCR\u304c\u5f97\u3089\u308c\u3066\u3082\u814b\u7aa9\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u967d\u6027\u306e\u60a3\u8005\u3060\u3063\u305f\u3002<\/p>\n \u60a3\u8005\u306f\u8853\u5f8c\u3001\u5185\u5206\u6ccc\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u7642\u6cd5\u3092\u542b\u3080\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u3092\u53d7\u3051\u308b\u7fa4\uff08\u5bfe\u7167\u7fa4\uff09\u3001<\/p>\n \u307e\u305f\u306f\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u306b\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u306e\u6295\u4e0e\u3092\u8ffd\u52a0\u3059\u308b\u7fa4\uff08\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u7fa4\uff09\u306b<\/p>\n \u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u306f2500mg\/m2<\/sup>\/\u65e5\u30922\u9031\u6295\u4e0e\u3001<\/p>\n 1\u9031\u4f11\u85ac\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3067\u6295\u4e0e\u3057\u3001\u6700\u521d\u306e50\u4f8b\u30676\u30b5\u30a4\u30af\u30eb\u306e\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u5f8c\u3001<\/p>\n 8\u30b5\u30a4\u30af\u30eb\u306b\u5ef6\u9577\u3055\u308c\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u7121\u518d\u767a\u751f\u5b58\u7387\uff08DFS\uff09\u3001<\/p>\n \u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee\u306b\u306f\u5168\u751f\u5b58\u7387\uff08OS\uff09\u306a\u3069\u304c\u542b\u307e\u308c\u305f\u3002<\/p>\n <\/p>\n \u65e5\u672c\u3068\u97d3\u56fd\u304b\u3089910\u4f8b\u304c\u767b\u9332\u3055\u308c\u3001\u6700\u5927\u306e\u89e3\u6790\u5bfe\u8c61\u96c6\u56e3\uff08FAS\uff09\u306f<\/p>\n \u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u7fa4443\u4f8b\u3001\u5bfe\u7167\u7fa4444\u4f8b\u3068\u306a\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u60a3\u8005\u80cc\u666f\u306f<\/p>\n \u4e21\u7fa4\u3067\u30d0\u30e9\u30f3\u30b9\u304c\u3068\u308c\u3066\u3044\u305f\u3002<\/p>\n <\/p>\n \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308bDFS\u306f\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u7fa4\u3067\u6709\u610f\u306b\u6539\u5584\u3057\u3001<\/p>\n \u30cf\u30b6\u30fc\u30c9\u6bd40.70\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a0.53-0.92\uff09\u3001p\uff1d0.01\u3068\u306a\u308a\u3001<\/p>\n 3\u5e74\u6642\u306b\u306f8.8\uff05\u306e\u5dee\u304c\u958b\u3044\u305f\u3002<\/p>\n OS\u3082\u3001\u30cf\u30b6\u30fc\u30c9\u6bd40.59\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a0.39-0.90\uff09\u3001p\uff1d0.01\u3068\u306a\u308a\u3001<\/p>\n 3\u5e74\u6642\u306b\u306f4.8\uff05\u306e\u5dee\u3092\u8a8d\u3081\u305f\u3002<\/p>\n <\/p>\n DFS\u3068OS\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u764c\u3001<\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u7d44\u7e54\u5b66\u7684\u6cbb\u7642\u52b9\u679c\u304c0\u30011a\u30011b\u306e\u7fa4\u3001<\/p>\n \u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u967d\u6027\u306e\u5834\u5408\u306b\u3001\u7279\u306b\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u306e\u4f75\u7528\u52b9\u679c\u304c\u9ad8\u304b\u3063\u305f\u3002<\/p>\n \u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u764c\u3067\u306f\u65e9\u671f\u306e\u518d\u767a\u306e\u6291\u5236\u304cOS\u306e\u5ef6\u9577\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u3001<\/p>\n \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u967d\u6027\u4e73\u764c\u3067\u3082\u4f75\u7528\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u3082<\/p>\n \u793a\u3055\u308c\u305f\u3002\u540c\u8a66\u9a13\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u3001\u5897\u7530\u6c0f\u306f<\/p>\n \u300c\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306f\u500b\u5225\u5316\u6cbb\u7642\u306e1\u3064\u306e\u790e\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u3053\u3068\u304c<\/p>\n \u8a3c\u660e\u3055\u308c\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u300d\u3068\u8a71\u3057\u305f\u3002<\/p>\n <\/p>\n \u3053\u306e\u8a66\u9a13\u3068\u540c\u69d8\u306b\u3001\u6cbb\u7642\u52b9\u679c\u304c\u5341\u5206\u3067\u3042\u308c\u3070\u305d\u306e\u6cbb\u7642\u3092\u7d99\u7d9a\u3059\u308b\u3001<\/p>\n \u3082\u3057\u304f\u306f\u305d\u306e\u5f8c\u306e\u6cbb\u7642\u3092\u8efd\u6e1b\u3059\u308b\u3001\u4e00\u65b9\u3001\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3067\u3042\u308c\u3070<\/p>\n \u65b0\u3057\u3044\u85ac\u5264\u3092\u4f7f\u3046\u3068\u3044\u3046\u30b3\u30f3\u30bb\u30d7\u30c8\u306b\u57fa\u3065\u304d\u3001\u73fe\u5728\u8907\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u304c<\/p>\n \u9032\u884c\u3057\u3066\u3044\u308b\u3002\u8853\u5f8c\u7642\u6cd5\u3068\u3057\u3066\u3001ER\u967d\u6027HER2\u9670\u6027\u4e73\u764c\u3067S-1\u3092\u8a55\u4fa1\u3059\u308b<\/p>\n POTENT\u8a66\u9a13\u3001\u8853\u524d\u5316\u5b66\u7642\u6cd5\u5f8c\u306e\u518d\u767a\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff08HR\uff09<\/p>\n \u967d\u6027HER2\u9670\u6027\u4e73\u764c\u3067CDK4\/6\u963b\u5bb3\u85acpalbociclib\u3092\u8a55\u4fa1\u3059\u308bPENELOPE\u8a66\u9a13\u3001<\/p>\n BRCA1\/2\u5909\u7570\u967d\u6027HER2\u9670\u6027\u4e73\u764c\u3067\u30aa\u30e9\u30d1\u30ea\u30d6\u3092\u8a55\u4fa1\u3059\u308bOlympiA\u8a66\u9a13\u3001<\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u3067\u764c\u304c\u907a\u6b8b\u3057\u305fHER2\u967d\u6027\u4e73\u764c\u3067T-DM1\u3092\u8a55\u4fa1\u3059\u308b<\/p>\n Katherine\u8a66\u9a13\u306a\u3069\u304c\u4ee3\u8868\u7684\u3067\u3042\u308b\u3002<\/p>\n <\/p>\n \u300c\u6211\u3005\u306f\u3001\u30db\u30eb\u30e2\u30f3\u9670\u6027\u4e73\u764c\u3084HER2\u967d\u6027\u4e73\u764c\u3067\u306f<\/p>\n \u6bd4\u8f03\u7684\u9ad8\u3044\u78ba\u7387\u3067\u764c\u306e\u5b8c\u5168\u6d88\u5931\uff08SpCR\uff09\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u3092\u3001<\/p>\n \u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u7d4c\u9a13\u304b\u3089\u5b66\u3093\u3067\u304d\u305f\u300d\u3068\u5897\u7530\u6c0f\u306f\u8ff0\u3079\u305f\u3002<\/p>\n 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