{"id":2136,"date":"2020-10-06T02:45:08","date_gmt":"2020-10-05T17:45:08","guid":{"rendered":"http:\/\/waraeba.net\/blog\/?p=2136"},"modified":"2020-10-06T02:50:55","modified_gmt":"2020-10-05T17:50:55","slug":"%e5%82%99%e5%bf%98%e9%8c%b2%ef%bc%9a%e6%97%a5%e7%b5%8c%e3%83%a1%e3%83%87%e3%82%a3%e3%82%ab%e3%83%ab%e3%82%88%e3%82%8a%e5%bc%95%e7%94%a8","status":"publish","type":"post","link":"https:\/\/waraeba.net\/blog\/?p=2136","title":{"rendered":"\u5099\u5fd8\u9332\uff1a\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb\u4ed6\u3088\u308a\u5f15\u7528"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">\u30b9\u30c6\u30ed\u30a4\u30c9\u306f\u514d\u75ab\u4ea2\u9032\u3068\u3044\u3046\u3082\u30461\u3064\u306e\u9854\u3092\u6301\u3064<\/h1>\n\n\n\n<p>2020\/09\/16<a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/author\/a043.html\">\u5c0f\u677f\u6a4b\u5f8b\u5b50\uff1d\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb<\/a><a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/search\/j01\/\">\u611f\u67d3\u75c7<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/search\/integrate\/search.html?words=%E3%82%B9%E3%83%86%E3%83%AD%E3%82%A4%E3%83%89&amp;sort=new\">\u30b9\u30c6\u30ed\u30a4\u30c9<\/a><\/li><li><a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/search\/integrate\/search.html?words=%E6%8A%97%E7%82%8E%E7%97%87%E8%96%AC&amp;sort=new\">\u6297\u708e\u75c7\u85ac<\/a><\/li><li><a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/search\/integrate\/search.html?words=COVID-19&amp;sort=new\">COVID-19<\/a><\/li><\/ul>\n\n\n\n<p>\u3000\u4eca\u5e74\u306b\u306a\u3063\u3066\u731b\u5a01\u3092\u632f\u308b\u3063\u3066\u3044\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\uff08COVID-19\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u3002\u3053\u308c\u307e\u3067\u306b\u306a\u3044\u72ec\u7279\u306e\u7279\u5fb4\u3092\u6301\u3064\u3053\u3068\u304b\u3089\u3001\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u3092\u60a9\u307e\u305b\u3001\u81e8\u5e8a\u73fe\u5834\u3067\u306f\u305d\u306e\u5bfe\u5fdc\u306b\u304a\u3044\u3066\u8a66\u884c\u932f\u8aa4\u306e\u65e5\u3005\u304c\u7d9a\u3044\u3066\u3044\u305f\u3002<br><br>\u3000\u3067\u3082\u3055\u3001SARS-CoV-2\u541b\u3001\u4eba\u985e\u306e\u82f1\u77e5\u3092\u306a\u3081\u3066\u3082\u3089\u3063\u3066\u306f\u56f0\u308b\u3088\u3002\u305d\u308d\u305d\u308d\u3001\u6211\u3005\u306f\u541b\u306b\u3069\u3046\u5bfe\u5fdc\u3059\u308c\u3070\u3044\u3044\u304b\u5206\u304b\u3063\u3066\u304d\u305f\u3002\u30bd\u30fc\u30b7\u30e3\u30eb\u30c7\u30a3\u30b9\u30bf\u30f3\u30b9\u3060\u306e\u3001\u624b\u6307\u885b\u751f\u3060\u306e\u3068\u3044\u3046\u4e88\u9632\u5bfe\u7b56\u3060\u3051\u3067\u306a\u304f\u3001\u8a3a\u65ad\u3068\u6cbb\u7642\u306b\u304a\u3051\u308b\u5bfe\u5fdc\u6cd5\u3060\u3063\u3066\u78ba\u7acb\u306e\u3081\u3069\u304c\u7acb\u3063\u3066\u304d\u305f\u306e\u3060\u3088\u2500\u2500\u3002\u305d\u3093\u306a\u6c17\u5206\u306b\u6d78\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u304c\u3001\u3053\u308c\u307e\u3067\u306b\u7d04250\u75c7\u4f8b\u3092\u7d4c\u9a13\u3057\u3066\u3044\u308b\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7b2c\u56db\u547c\u5438\u5668\u5185\u79d1\u533b\u9577\u306e\u6cc9\u4fe1\u6709\u6c0f\u3068\u3001JCHO\u6771\u4eac\u5c71\u624b\u30e1\u30c7\u30a3\u30ab\u30eb\u30bb\u30f3\u30bf\u30fc\u306e\u5fb3\u7530\u5747\u6c0f\u306e2\u6642\u9593\u4f59\u308a\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u5bfe\u8ac7\u3060\u3063\u305f\u3002<br><br>\u5bfe\u8ac7\u25ce\u30b3\u30ed\u30ca\u80ba\u708e\u306e\u5b9f\u50cf\u306b\u8feb\u308b\u3010\u305d\u306e1\uff5e3\u3011<br>\u25c6<a href=\"https:\/\/medical.nikkeibp.co.jp\/leaf\/mem\/pub\/series\/hitoshi\/202008\/566855.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30b3\u30ed\u30ca\u80ba\u708e\u306e\u6539\u5584or\u60aa\u5316\u306fCT\u50cf\u3067\u4e88\u60f3\u3067\u304d\u308b<\/a><br>\u25c6<a href=\"https:\/\/medical.nikkeibp.co.jp\/leaf\/mem\/pub\/series\/hitoshi\/202008\/566857.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u300c\u30b3\u30ed\u30ca\u80ba\u708e\u304c\u6025\u5909\u3057\u3066\u633f\u7ba1\u300d\u306f\u56de\u907f\u3067\u304d\u308b<\/a><br>\u25c6<a href=\"https:\/\/medical.nikkeibp.co.jp\/leaf\/mem\/pub\/series\/hitoshi\/202009\/566858.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30b3\u30ed\u30ca\u80ba\u708e\u6cbb\u7642\u306e\u30ab\u30ae\u306f\u6297\u708e\u75c7\u85ac<\/a><br><br>\u3000\u7d42\u59cb\u63a7\u3048\u3081\u3067\u81e8\u5e8a\u5bb6\u3068\u3057\u3066\u614e\u91cd\u306a\u59ff\u52e2\u3092\u5d29\u3055\u306a\u3044\u6cc9\u6c0f\u3060\u3063\u305f\u304c\u3001\u3053\u308c\u307e\u3067\u306e\u7d4c\u9a13\u304b\u3089\u3001COVID-19\u306f\u6cbb\u7642\u53ef\u80fd\u306a\u75be\u60a3\u3067\u3042\u308a\u3001\u6b7b\u4ea1\u7387\u306f\u307e\u3060\u307e\u3060\u4e0b\u3052\u3089\u308c\u308b\u3068\u306e\u81ea\u4fe1\u304c\u3001\u305d\u306e\u8a00\u8449\u306e\u9685\u3005\u306b\u306b\u3058\u3093\u3067\u3044\u305f\u3002<br><br>\u3000\u73fe\u5728\u3001COVID-19\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u56fd\u5185\u3067\u627f\u8a8d\u3055\u308c\u3001\u6295\u4e0e\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e<a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/drugdic\/prd\/62\/62504A3A1029.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb<\/a>\u3068\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306e<a href=\"https:\/\/medical.nikkeibp.co.jp\/inc\/all\/drugdic\/prd\/24\/2454002F3020.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3<\/a>\u306e2\u5264\u3002\u7279\u306b\u6cc9\u6c0f\u304c\u671f\u5f85\u3059\u308b\u306e\u304c\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u3060\u3002\u300c\u6297\u708e\u75c7\u85ac\u3060\u3051\u3067\u6cbb\u7652\u3057\u305f\u75c7\u4f8b\u304c\u51fa\u3066\u304d\u3066\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\uff09\u3092\u8ef8\u3068\u3057\u305f\u6297\u708e\u75c7\u6cbb\u7642\u3092\u7a4d\u6975\u7684\u306b\u5b9f\u65bd\u3057\u3066\u3044\u308b\u300d\u3068\u8aac\u660e\u3059\u308b\u3002<br><br>\u3000\u5bfe\u8ac7\u76f8\u624b\u306e\u5fb3\u7530\u6c0f\u3082\u3001\u300cCOVID-19\u306e\u91cd\u75c7\u5316\u306b\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u304c\u5f37\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u6cbb\u7642\u304c\u91cd\u8981\u306b\u306a\u308b\u3060\u308d\u3046\u300d\u3068\u547c\u5fdc\u3002COVID-19\u3067\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u304c\u5f15\u304d\u91d1\u3067\u306f\u3042\u308b\u304c\u3001\u305d\u308c\u306b\u5f15\u304d\u7d9a\u304d\u5bbf\u4e3b\u5074\u306e\u514d\u75ab\u5fdc\u7b54\u304c\u904e\u5270\u306b\u306a\u308b\u3053\u3068\u304c\u554f\u984c\u3067\u3042\u308b\u306e\u3060\u304b\u3089\u3001\u305d\u306e\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u3044\u3046\u3002<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b9\u30c6\u30ed\u30a4\u30c9\u306f\u30ea\u30f3\u30d1\u7403\u3060\u3051\u3067\u306a\u304f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u3082\u6291\u5236<\/h3>\n\n\n\n<p>\u3000\u3053\u3053\u3067\u3001\u306a\u305c\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u304cCOVID-19\u306b\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u8003\u3048\u3066\u307f\u305f\u3044\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u50cd\u304d\u306b\u8a73\u3057\u3044\u4eac\u90fd\u5927\u5b66\u30a6\u30a4\u30eb\u30b9\u30fb\u518d\u751f\u533b\u79d1\u5b66\u7814\u7a76\u6240\u514d\u75ab\u5236\u5fa1\u5206\u91ce\u6559\u6388\u306e\u751f\u7530\u5b8f\u4e00\u6c0f\u306f\u3001\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306b\u306f\u30ea\u30f3\u30d1\u7403\u306b\u52a0\u3048\u3066\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\u306e\u50cd\u304d\u3082\u6291\u3048\u308b\u52b9\u679c\u304c\u3042\u308b\u300d\u3068\u8aac\u660e\u3059\u308b\u3002\u300c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3059\u308b\u304c\u3001\u305d\u306e\u7523\u751f\u7d30\u80de\u3092\u6291\u5236\u3067\u304d\u308c\u3070\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306e\u6839\u5143\u3092\u6291\u3048\u3089\u308c\u308b\u3060\u308d\u3046\u300d\u3068\u3082\u8003\u5bdf\u3059\u308b\u3002<br><br>\u3000\u305d\u306e\u4e00\u65b9\u3067\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306f\u30ea\u30f3\u30d1\u7403\u306e\u50cd\u304d\u3092\u3082\u6291\u3048\u308b\u305f\u3081\u3001\u6297\u4f53\u7523\u751f\u3084\u611f\u67d3\u7d30\u80de\u306e\u6392\u9664\u304c\u4e0d\u5341\u5206\u3068\u306a\u308a\u3001\u611f\u67d3\u75c7\u304c\u60aa\u5316\u3059\u308b\u5371\u967a\u6027\u304c\u3042\u308b\u3002<br><br>\u3000\u5b9f\u969b\u3001\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306f\u3001\u540c\u3058\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b\u91cd\u75c7\u6025\u6027\u547c\u5438\u5668\u75c7\u5019\u7fa4\uff08SARS\uff09\u3001\u4e2d\u6771\u547c\u5438\u5668\u75c7\u5019\u7fa4\uff08MERS\uff09\u306b\u304a\u3051\u308b\u6295\u4e0e\u3067\u6709\u5bb3\u4e8b\u8c61\u3092\u751f\u3058\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u5f53\u521d\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306e\u4f7f\u7528\u306b\u306f\u6d88\u6975\u7684\u3067\u3001\u81e8\u5e8a\u7814\u7a76\u306b\u9650\u3063\u3066\u4f7f\u7528\u3059\u308b\u3088\u3046\u6c42\u3081\u3066\u3044\u305f\uff08SARS\u3001MERS\u3068COVID-19\u3067\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u3078\u306e\u53cd\u5fdc\u6027\u304c\u7570\u306a\u308b\u306e\u306f\u306a\u305c\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u5225\u306e\u8a18\u4e8b\u3067\u7d39\u4ecb\u4e88\u5b9a\uff09\u3002\u305d\u306e\u65b9\u91dd\u3092180\u5ea6\u8ee2\u63db\u3057\u305f\u306e\u304c\u30019\u67082\u65e5\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306b\u3088\u308bCOVID-19\u306e\u6b7b\u4ea1\u7387\u6e1b\u5c11\u52b9\u679c\u304c\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u78ba\u8a8d\u3055\u308c\u305f\u306e\u304c\u304d\u3063\u304b\u3051\u3060\u3063\u305f\uff08\u95a2\u9023\u8a18\u4e8b\uff1a<a href=\"https:\/\/medical.nikkeibp.co.jp\/leaf\/mem\/pub\/report\/t344\/202009\/566986.html\" target=\"_blank\" rel=\"noreferrer noopener\">WHO\u304c\u91cd\u75c7\u65b0\u578b\u30b3\u30ed\u30ca\u3078\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u63a8\u5968<\/a>\uff09\u3002<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b9\u30c6\u30ed\u30a4\u30c9\u306b\u306f\u514d\u75ab\u3092\u5897\u5f37\u3059\u308b\u4f5c\u7528\u3082\u3042\u308b<\/h3>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/medical.nikkeibp.co.jp\/mem\/pub\/eye\/202009\/images\/thumb_567037_sum0915.jpg?w=640&#038;ssl=1\" alt=\"\" data-recalc-dims=\"1\"\/><\/figure>\n\n\n\n<p>\u3000\u69d8\u3005\u306a\u75be\u60a3\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u3060\u304c\u3001\u3082\u3068\u3082\u3068\u306f\u751f\u4f53\u5185\u306b\u5b58\u5728\u3059\u308b\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\uff08\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\uff09\u306b\u7531\u6765\u3059\u308b\u3002<br><br>\u3000\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u751f\u4f53\u5185\u3067\u306e\u50cd\u304d\u306b\u3064\u3044\u3066\u751f\u7530\u6c0f\u306f\u300c\u8840\u7cd6\u4e0a\u6607\u52b9\u679c\u306a\u3069\u69d8\u3005\u306a\u6a5f\u80fd\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u305d\u308c\u306f\u5168\u3066\u751f\u4f53\u9632\u5fa1\u6a5f\u80fd\u306b\u95a2\u9023\u3059\u308b\u3002\u307e\u305f\u3001\u305d\u306e\u5206\u6ccc\u306f\u30b9\u30c8\u30ec\u30b9\u8ca0\u8377\u3067\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u751f\u4f53\u9632\u5fa1\u30db\u30eb\u30e2\u30f3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u300d\u3068\u8aac\u660e\u3059\u308b\u3002<br><br>\u3000\u305f\u3060\u3057\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u6291\u5236\u52b9\u679c\u306f\u751f\u4f53\u9632\u5fa1\u3068\u306f\u76f8\u53cd\u3059\u308b\u6a5f\u80fd\u3060\u3002\u305d\u306e\u77db\u76fe\u306b\u7591\u554f\u3092\u611f\u3058\u305f\u751f\u7530\u6c0f\u3089\u304c\u3001\u300c\u751f\u4f53\u5185\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u514d\u75ab\u529b\u3092\u9ad8\u3081\u3066\u3044\u308b\u300d\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/j.immuni.2018.01.004\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.immuni.2018.01.004<\/a>\uff09\u306e\u306f\u30012018\u5e74\u306e\u3053\u3068\u3002\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306fT\u30ea\u30f3\u30d1\u7403\u306e\u4f53\u5185\u5faa\u74b0\u3068\u514d\u75ab\u5fdc\u7b54\u80fd\u306e\u65e5\u5185\u5909\u52d5\u3092\u5236\u5fa1\u3057\u3001\u751f\u4f53\u306e\u514d\u75ab\u529b\u3092\u9ad8\u3081\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002\u5b9f\u969b\u3001\u611f\u67d3\u304c\u751f\u3058\u308b\u3068\u4f53\u5185\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u6fc3\u5ea6\u306f\u4e0a\u6607\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u751f\u3058\u3066\u3044\u308b\u3068\u3082\u3044\u3046\u3002<br><br>\u3000\u3059\u306a\u308f\u3061\u3001\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6295\u4e0e\u3059\u308b\u9ad8\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306f\u514d\u75ab\u3092\u6291\u5236\u3059\u308b\u304c\u3001\u305d\u306e\u6570\u5206\u306e1\u7a0b\u5ea6\u306e\u4f4e\u7528\u91cf\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u306f\u514d\u75ab\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u3042\u308b\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u306b\u306f\u6fc3\u5ea6\u6b21\u7b2c\u3067\u771f\u9006\u306a\u4f5c\u7528\u3092\u751f\u3058\u308b2\u3064\u306e\u9854\u304c\u3042\u308b\u306e\u3060\u3002<br><br>\u3000\u751f\u7530\u6c0f\u306f\u3001\u300c\u73fe\u6bb5\u968e\u3067\u306f\u6839\u62e0\u306e\u306a\u3044\u5984\u60f3\u3060\u304c\u3001\u3082\u3057\u304b\u3057\u305f\u3089\u30b9\u30c6\u30ed\u30a4\u30c9\u306f\u75c5\u539f\u4f53\u304c\u4fb5\u5165\u3057\u3066\u304d\u305f\u969b\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u60f9\u8d77\u3059\u308b\u304c\u3001\u305d\u306e\u5206\u6ccc\u304c\u3042\u308b\u7a0b\u5ea6\u307e\u3067\u9ad8\u307e\u308b\u3068\u3001\u9006\u306b\u514d\u75ab\u6a5f\u80fd\u3092\u6291\u3048\u308b\u30d6\u30ec\u30fc\u30ad\u3068\u3057\u3066\u50cd\u304f\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u6a5f\u69cb\u3092\u6709\u3059\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u8a9e\u308b\u3002<br><br>\u30001950\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306f\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306a\u3069\u306e\u526f\u814e\u76ae\u8cea\u30db\u30eb\u30e2\u30f3\u306e\u767a\u898b\u3068\u69cb\u9020\u3001\u751f\u7406\u5b66\u7684\u4f5c\u7528\u306e\u767a\u898b\u306b\u6388\u4e0e\u3055\u308c\u305f\u3002\u305d\u306e\u767a\u898b\u3092\u57fa\u306b\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u304c\u5b9f\u7528\u5316\u3055\u308c\u3001\u69d8\u3005\u306a\u75be\u60a3\u3092\u60a3\u3046\u591a\u304f\u306e\u60a3\u8005\u3092\u6551\u3063\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u672c\u6765\u306e\u6a5f\u80fd\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u514d\u75ab\u5897\u5f37\u4f5c\u7528\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\u307b\u3093\u306e\u6570\u5e74\u524d\u3067\u3057\u304b\u306a\u3044\u3002\u3055\u3089\u306b\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u306f\u4f53\u5185\u6642\u8a08\u306e\u8abf\u6574\u4f5c\u7528\u304c\u3042\u308b\u306a\u3069\u306e\u65b0\u305f\u306a\u77e5\u898b\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002<br><br>\u3000\u30b3\u30ed\u30ca\u798d\u3092\u5dfb\u304d\u8d77\u3053\u3057\u3001\u5168\u4e16\u754c\u3092\u6df7\u4e71\u3055\u305b\u305fCOVID-19\u306b\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u3002\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u305d\u308c\u3060\u3051\u3067\u591a\u304f\u306e\u60a3\u8005\u3092\u6551\u3046\u3053\u3068\u306b\u306a\u308b\u3060\u308d\u3046\u3002\u3055\u3089\u306b\u3001\u300c\u306a\u305c\u6709\u52b9\u306a\u306e\u304b\uff1f\u300d\u3068\u3044\u3046\u554f\u3044\u3092\u7a81\u304d\u8a70\u3081\u308c\u3070\u3001COVID-19\u306e\u3088\u3046\u306a\u611f\u67d3\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306a\u3069\u514d\u75ab\u304c\u95a2\u9023\u3059\u308b\u69d8\u3005\u306a\u75be\u60a3\u306e\u77e5\u3089\u308c\u3056\u308b\u75c5\u614b\u306e\u89e3\u660e\u306b\u3082\u3064\u306a\u304c\u308a\u305d\u3046\u3060\u3002\u305d\u3093\u306a\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u3092\u751f\u7530\u6c0f\u306e\u8a71\u3092\u805e\u304d\u306a\u304c\u3089\u611f\u3058\u305f\u3002<br><br>\u3000\u3044\u3064\u307e\u3067\u3082COVID-19\u306b\u7ffb\u5f04\u3055\u308c\u3066\u306a\u308b\u3082\u306e\u304b\u3001\u4eca\u56de\u306e\u4e16\u754c\u7684\u6d41\u884c\u3092\u9006\u624b\u306b\u53d6\u3063\u3066\u533b\u5b66\u306e\u3055\u3089\u306a\u308b\u9032\u6b69\u3092\u3064\u304b\u307f\u53d6\u308d\u3046\u3067\u306f\u306a\u3044\u304b\uff01<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-7\u53d7\u5bb9\u4f53\u3068CXCR4\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u306e\u5206\u5e03\u3068\u5fdc\u7b54\u306e\u65e5\u5468\u632f\u52d5\u3092\u4fc3\u9032\u3057\u307e\u3059<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0020\">\u30cf\u30a4\u30e9\u30a4\u30c8<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>\u2022\u2022<\/strong>\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001T\u7d30\u80de\u306b\u304a\u3051\u308bIL-7R\u767a\u73fe\u306e\u65e5\u5468\u632f\u52d5\u3092\u4fc3\u9032\u3057\u307e\u3059<\/li><li><strong>\u2022\u2022<\/strong>\u30ea\u30ba\u30df\u30ab\u30eb\u306aIL-7R\u767a\u73fe\u306f\u3001CXCR4\u767a\u73fe\u3092\u4ecb\u3057\u3066T\u7d30\u80de\u306e\u518d\u5206\u5e03\u3092\u8a98\u5c0e\u3057\u307e\u3059<\/li><li><strong>\u2022\u2022<\/strong>\u30ea\u30f3\u30d1\u5668\u5b98\u306b\u304a\u3051\u308bT\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u84c4\u7a4d\u306f\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u5f37\u5316\u3057\u307e\u3059<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0010\">\u6982\u8981<\/h2>\n\n\n\n<p>\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u5f37\u529b\u306a\u6297\u708e\u75c7\u4f5c\u7528\u3068\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3092\u6301\u3064\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306fT\u7d30\u80de\u3067\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-7\u53d7\u5bb9\u4f53\uff08IL-7R\uff09\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u751f\u7406\u5b66\u7684\u6fc3\u5ea6\u3067T\u7d30\u80de\u306e\u6052\u5e38\u6027\u3068\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001IL-7R\u03b1\u907a\u4f1d\u5b50\u5ea7\u306e\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30de\u30a6\u30b9T\u7d30\u80de\u3067IL-7R\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u3001\u771f\u591c\u4e2d\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001\u6b63\u5348\u306b\u8c37\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306eIL-7R\u306e\u65e5\u4e2d\u306e\u8a98\u5c0e\u306f\u3001\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53CXCR4\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u306e\u751f\u5b58\u3068\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u813e\u81d3\u3001\u304a\u3088\u3073\u8840\u6db2\u9593\u306e\u518d\u5206\u5e03\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u3067\u306f\u3001\u591c\u9593\u306e\u813e\u81d3\u306b\u304a\u3051\u308bT\u7d30\u80de\u306e\u84c4\u7a4d\u306b\u3088\u308a\u3001\u53ef\u6eb6\u6027\u6297\u539f\u304a\u3088\u3073\u5168\u8eab\u6027\u7d30\u83cc\u611f\u67d3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u304c\u5897\u5f37\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0015\">\u30b0\u30e9\u30d5\u30a3\u30ab\u30eb\u306a\u62bd\u8c61<\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/879fc8c4-c0f9-40ec-b46c-396100549c59\/fx1.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebfx1\" data-recalc-dims=\"1\"\/><figcaption><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/879fc8c4-c0f9-40ec-b46c-396100549c59\/fx1.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/000676a4-034e-48b4-8bcb-539bbb88c837\/fx1_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=fx1.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0025\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.cell.com\/action\/doSearch?searchType=quick&amp;occurrences=all&amp;ltrlSrch=true&amp;searchScope=series&amp;searchText=glucocorticoid&amp;seriesISSN=1074-7613\">\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/action\/doSearch?searchType=quick&amp;occurrences=all&amp;ltrlSrch=true&amp;searchScope=series&amp;searchText=interleukin-7&amp;seriesISSN=1074-7613\">\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-7<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/action\/doSearch?searchType=quick&amp;occurrences=all&amp;ltrlSrch=true&amp;searchScope=series&amp;searchText=diurnal%20rhythm&amp;seriesISSN=1074-7613\">\u65e5\u5468\u30ea\u30ba\u30e0<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/action\/doSearch?searchType=quick&amp;occurrences=all&amp;ltrlSrch=true&amp;searchScope=series&amp;searchText=T%20cell&amp;seriesISSN=1074-7613\">T\u7d30\u80de<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/action\/doSearch?searchType=quick&amp;occurrences=all&amp;ltrlSrch=true&amp;searchScope=series&amp;searchText=CXCR4&amp;seriesISSN=1074-7613\">CXCR4<\/a><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0030\">\u524d\u66f8\u304d<\/h2>\n\n\n\n<p>\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3001\u8a8d\u77e5\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306a\u3069\u306e\u591a\u69d8\u306a\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u5bc4\u4e0e\u3059\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u307e\u305f\u5f37\u529b\u306a\u6297\u708e\u75c7\u304a\u3088\u3073\u514d\u75ab\u6291\u5236\u52b9\u679c\u3092\u6301\u3061\u3001\u81e8\u5e8a\u8a3a\u7642\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u526f\u814e\u76ae\u8cea\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u306b\u53cd\u5fdc\u3057\u3066\u526f\u814e\u76ae\u8cea\u306b\u3088\u3063\u3066\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067\u7523\u751f\u3055\u308c\u307e\u3059\u3002\u4eba\u9593\u306e\u5834\u5408\u3001\u8840\u4e2d\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u30ec\u30d9\u30eb\u306f\u671d\u306b\u30d4\u30fc\u30af\u306b\u9054\u3057\u3001\u65e5\u4e2d\u3068\u591c\u306e\u6700\u521d\u306e\u90e8\u5206\u3067\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u30de\u30a6\u30b9\u306a\u3069\u306e\u591c\u884c\u6027\u306e\u52d5\u7269\u3067\u306f\u3001\u3053\u306e\u6982\u65e5\u5909\u52d5\u306f\u9006\u8ee2\u3057\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u7d30\u80de\u8cea\u5185\u306e\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08GR\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u6b21\u306b\u3001GR\u306f\u6838\u306b\u4f1d\u9054\u3055\u308c\u3001\u305d\u3053\u3067\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u5fdc\u7b54\u8981\u7d20\uff08GRE\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib3\">Ashwell et al\u3002\u30012000<\/a>\uff09\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001CD4&nbsp;<sup>+<\/sup>&nbsp;CD8&nbsp;<sup>+<\/sup>\u672a\u6210\u719f\u80f8\u817a\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib38\">Screpanti et al\u3002\u30011989<\/a>\uff09\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001T\u7d30\u80de\u306e\u767a\u9054\u306fGR\u6b20\u640d\u30de\u30a6\u30b9\uff08<em>Nr3c1&nbsp;<\/em><sup>\u2013 \/ \u2013<\/sup>\uff09\u3067\u306f\u640d\u306a\u308f\u308c\u3066\u3044\u307e\u305b\u3093\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib36\">Purton et al\u3002\u30012000<\/a>\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u514d\u75ab\u7cfb\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u751f\u7406\u5b66\u7684\u6a5f\u80fd\u306f\u4e0d\u660e\u306a\u307e\u307e\u3067\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u514d\u75ab\u7cfb\u3068\u76f4\u63a5\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u305d\u308c\u3089\u306fT\u7d30\u80de\u306b\u304a\u3044\u3066IL-7\u53d7\u5bb9\u4f53\u03b1\u9396\uff08IL-7R\u03b1\uff09\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib14\">Franchimont et al\u3002\u30012002<\/a>\uff09\u3002IL-7\u3001\u514d\u75ab\u7cfb\u306e\u767a\u9054\u3068\u7dad\u6301\u306b\u91cd\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib31\">Mazzucchelli and Durum\u30012007\u5e74<\/a>\uff09\u3001\u4e00\u822c\u7684\u306a\u03b3\u9396\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3059\u3002IL-7R\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001\u8ee2\u5199\u56e0\u5b50\u30b7\u30b0\u30ca\u30eb\u30c8\u30e9\u30f3\u30b9\u30c7\u30e5\u30fc\u30b5\u30fc\u304a\u3088\u3073\u8ee2\u5199\u6d3b\u6027\u5316\u56e0\u5b50\uff08STAT\uff095\u3068\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb3-\u30ad\u30ca\u30fc\u30bc\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u306e\u5897\u6b96\u3001\u751f\u5b58\u3001\u304a\u3088\u3073\u5206\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u4ee5\u524d\u3001GR\u304cIL-7R\u03b1\u907a\u4f1d\u5b50\u5ea7\u306e\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306eGRE\u306b\u7d50\u5408\u3057\u3001\u305d\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib29\">Lee et al\u3002\u30012005<\/a>\uff09\u3002\u5b9f\u969b\u3001IL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306e\u6a19\u7684\u6b20\u5931\u306f\u3001IL-7R\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u672b\u68a2T\u7d30\u80de\u306e\u751f\u5b58\u3068\u5fdc\u7b54\u3092\u640d\u306a\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib1\">\u963f\u90e8\u307b\u304b\u30012015\u5e74<\/a>\uff09\u3002\u3055\u3089\u306b\u3001IL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u6b20\u640d\u30de\u30a6\u30b9\u306f\u3001T\u7d30\u80de\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u3092\u5b8c\u5168\u306b\u6b20\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304cIL-7R\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308aT\u7d30\u80de\u306e\u6052\u5e38\u6027\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6982\u65e5\u30ea\u30ba\u30e0\u306f\u514d\u75ab\u7cfb\u306b\u304b\u306a\u308a\u306e\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u795e\u7d4c\u4fe1\u53f7\u306f\u3001\u30ea\u30f3\u30d1\u7bc0\u306b\u304a\u3051\u308b\u65e5\u4e2d\u306e\u30ea\u30f3\u30d1\u7403\u518d\u5faa\u74b0\u3092\u4ecb\u3057\u3066\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib41\">\u9234\u6728\u307b\u304b\u30012016\u5e74<\/a>\uff09\u3002\u3088\u308a\u76f4\u63a5\u7684\u306b\u306f\u3001\u30ea\u30f3\u30d1\u7403\u6642\u8a08\u907a\u4f1d\u5b50<em>Arntl<\/em>\u306f\u3001\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53CCR7\u304a\u3088\u3073\u30b9\u30d5\u30a3\u30f3\u30b4\u30b7\u30f3-1-\u30ea\u30f3\u9178\u53d7\u5bb9\u4f531\uff08S1PR1\uff09\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30ea\u30f3\u30d1\u7bc0\u3092\u4ecb\u3057\u305f\u8f38\u9001\u3068\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib9\">Druzd et al\u3002\u30012017<\/a>\uff09\u3002\u305d\u308c\u3089\u306e\u65e5\u4e2d\u306e\u7523\u751f\u306e\u305f\u3081\u306b\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u91cd\u8981\u306a\u6982\u65e5\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001<em>Per2<\/em>\u3084<em>Nfil3<\/em>\u306a\u3069\u306e\u5185\u56e0\u6027\u6642\u8a08\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u3001\u4f53\u5185\u5168\u4f53\u306e\u6982\u65e5\u5909\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib40\">So et al\u3002\u30012009<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u708e\u75c7\u6027\u6761\u4ef6\u4e0b\u304a\u3088\u3073\u597d\u4e2d\u7403\u52d5\u54e1\u4e0b\u3067\u306e\u80ba\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u30b1\u30e2\u30ab\u30a4\u30f3CXCL5\u767a\u73fe\u306e\u6982\u65e5\u5909\u5316\u3092\u5236\u5fa1\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib15\">Gibbs et al\u3002\u30012014<\/a>\uff09\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u81ea\u7136\u514d\u75ab\u304a\u3088\u3073\u7372\u5f97\u514d\u75ab\u53cd\u5fdc\u306b\u304a\u3044\u3066\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304cIL-7R\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u306e\u6052\u5e38\u6027\u3092\u8abf\u7bc0\u3057\u3001\u65e5<em>\u5468\u671f<\/em>\u3067\u6a5f\u80fd\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001IL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fcGRE\u5909\u7570\u4f53\u3068T\u7d30\u80de\u7279\u7570\u7684GR\u6b20\u640d\u30de\u30a6\u30b9\uff08<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\uff09\u3092<em>\u5206\u6790\u3057<\/em>\u307e\u3057\u305f\u3002IL-7R\u306f\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u3067GR\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u3001CXCR4\u306e\u767a\u73fe\u3092\u4ecb\u3057\u3066\u3001T\u7d30\u80de\u306e\u751f\u5b58\u3068\u30ea\u30f3\u30d1\u7bc0\u3001\u813e\u81d3\u3001\u30d1\u30a4\u30a8\u30eb\u677f\u3078\u306e\u52d5\u54e1\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001T\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u306f\u3001\u30de\u30a6\u30b9\u306e\u591c\u9593\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u5897\u5f37\u3057\u307e\u3057\u305f\u3002\u307e\u3068\u3081\u308b\u3068\u3001\u6211\u3005\u306e\u7d50\u679c\u306f\u3001\u9069\u5fdc\u514d\u75ab\u304c\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u3088\u308b\u65e5\u4e2d\u306e\u5236\u5fa1\u4e0b\u306b\u3042\u308a\u3001\u5185\u5206\u6ccc\u7cfb\u3068\u514d\u75ab\u7cfb\u306e\u9593\u306e\u65b0\u3057\u3044\u30ea\u30f3\u30af\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0035\">\u7d50\u679c<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306f\u30ea\u30f3\u30d1\u5668\u5b98\u306b\u304a\u3051\u308bIL-7R\u767a\u73fe\u3068T\u7d30\u80de\u6570\u306e\u65e5\u5185\u5909\u5316\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/h3>\n\n\n\n<p>\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001T\u7d30\u80de\u6052\u5e38\u6027\u304a\u3088\u3073\u6d3b\u6027\u3092\u8abf\u7bc0\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001<em>in vivo\u3067<\/em>\u3001\u6211\u3005\u306f\u3001T\u7d30\u80de\u7279\u7570\u7684\u306eGR\u6b20\u640d\uff08\u4e2dIL-7R\u306e\u767a\u73fe\u3092\u8abf\u3079<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\uff09\u30de\u30a6\u30b9\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S1<\/a>&nbsp;A\uff09\u3002IL-7R\u306e\u767a\u73fe\u306f\u3001IL-7R\u5f0f\uff08\u6e1b\u5c11\u3092\u793a\u3057\u305f\u80f8\u817a\u8abf\u7bc0T\uff08Treg\u7d30\u80de\uff09\u7d30\u80de\u3092\u9664\u3044\u3066\u3001\u307b\u3068\u3093\u3069\u306e\u80f8\u817a\u7d30\u80de\u306b\u304a\u3044\u3066\u5909\u5316\u3057\u306a\u304b\u3063\u305f<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S1<\/a>&nbsp;B\u3068S1C\uff09\u304c\u3001\u6b63\u5e38\u306a\u767a\u9054\u3092\u65bd\u884c\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S1<\/a>&nbsp;D-S1H\u3092\uff09\u3002\u672b\u68a2\u3067\u306f\u3001IL-7R\u306e\u767a\u73fe\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u6e1b\u5c11\u3057<em>\u307e\u3057\u305f<\/em>\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f3<\/a>1A\uff09\u3002\u3055\u3089\u306b\u3001IL-7R\u306e\u4f4e\u4e0b\u306f\u591c\u9593\u306b\u306e\u307f\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f3<\/a>1B\uff09\u3002IL-7R\u306e\u767a\u73fe\u306f\u65e5\u5468\u671f\u3067\u5909\u5316\u3057\u3001Zeitgeber\u6642\u9593\uff08ZT\u300124\u6642\u9593\u306e\u660e\/\u6697\u30b5\u30a4\u30af\u30eb\u3067\u30e9\u30a4\u30c8\u30aa\u30f3\u3092\u6642\u95930\u3068\u3057\u3066\u5b9a\u7fa9\uff0916\uff08\u591c\u306e\u6642\u70b9\uff09\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u306fZT4\uff08\u663c\u306e\u6642\u70b9\uff09\u306b\u6700\u4e0b\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u30de\u30a6\u30b9\u3067\u3059\u304c\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f1\u65e5\u3092\u901a\u3057\u3066\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f3<\/a>1C\uff09\u3002\u3053\u306e\u5909\u5316\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u30ec\u30d9\u30eb\u306e\u65e5\u5185\u5909\u52d5\u306b\u7d9a\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib15\">Gibbs et al\u3002\u30012014<\/a>\uff09\u3002IL-7R\u767a\u73fe\u306e\u65e5\u5185\u5909\u52d5\u306fmRNA\u30ec\u30d9\u30eb\u3067\u8abf\u7bc0\u3055\u308c\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u5931\u308f\u308c\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f31<\/a>&nbsp;D\uff09\u3001GR\u304c\u672b\u68a2T\u7d30\u80de\u306b\u304a\u3051\u308bIL-7R\u767a\u73fe\u306e\u65e5\u5185\u30ea\u30ba\u30e0\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304cT\u7d30\u80de\u6a5f\u80fd\u306e\u65e5\u5185\u5909\u5316\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/1f05f8a6-c21c-474d-b7b6-c250d72e6948\/gr1.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr1\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>1GR\u306fIL-7R\u306e\u767a\u73fe\u3068T\u7d30\u80de\u306e\u5206\u5e03\u3092\u65e5\u4e2d\u5236\u5fa1\u3059\u308b<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/1f05f8a6-c21c-474d-b7b6-c250d72e6948\/gr1.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/f995c7c2-16c9-42f4-8a59-c0928623bf17\/gr1_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr1.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<p>\u3053\u306e\u53ef\u80fd\u6027\u3092\u63a2\u308b\u305f\u3081\u306b\u3001\u65e5\u4e2d\u306e\u672b\u68a2\u30ea\u30f3\u30d1\u5668\u5b98\u306eT\u7d30\u80de\u6570\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u5faa\u74b0\u30ea\u30f3\u30d1\u7403\u6570\u306f\u3001\u30d2\u30c8\u672b\u68a2\u8840\u3067\u5909\u52d5\u3057\u3001\u591c\u9593\u306b\u4e0a\u6607\u3057\u3001\u65e5\u4e2d\u306b\u4f4e\u4e0b\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib21\">\u30cf\u30a6\u30b9\u3068\u30b9\u30e2\u30ec\u30f3\u30b9\u30ad\u30fc\u30011999\u5e74<\/a>\uff09\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u306e\u8840\u6db2\u3067\u306f\u3001CD4&nbsp;<sup>+<\/sup>&nbsp;T\u3001CD8&nbsp;<sup>+<\/sup>&nbsp;T\u3001\u304a\u3088\u3073Treg\u7d30\u80de\u306e\u7d76\u5bfe\u6570\u304c\u5909\u52d5\u3057\u3001ZT4\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001ZT16\u306b\u6700\u4e0b\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f3<\/a>1E\uff09\u3002\u5bfe\u7167\u7684\u306b\u3001\u8840\u4e2d\u306eT\u7d30\u80de\u6570\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306e\u65b9\u304c\u5bfe\u7167\u3088\u308a\u3082\u5c11\u306a\u304f\u3001\u663c\u3068\u591c\u306e\u5dee\u306f\u5931\u308f\u308c\u307e\u3057\u305f\u3002\u8840\u6db2\u4e2d\u306eT\u7d30\u80de\u6570\u306e\u65e5\u5909\u5316\u306b\u3088\u308a\u3001T\u7d30\u80de\u306f\u65e5\u4e2d\u306b\u30ea\u30f3\u30d1\u7d44\u7e54\u3068\u8840\u6db2\u306e\u9593\u3092\u518d\u5faa\u74b0\u3059\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3057\u305f\u3002\u78ba\u304b\u306b\u3001\u30ea\u30f3\u30d1\u7bc0\u306eT\u7d30\u80de\u6570\u306f\u3001ZT12\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001ZT0\u306b\u6700\u4e0b\u70b9\u304c\u3042\u308b\u65e5\u5185\u5909\u52d5\u3092\u793a\u3057\u3001\u3053\u306e\u5909\u52d5\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u5931\u308f\u308c<em>\u307e\u3057<\/em>\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f3<\/a>1F\uff09\u3001\u4ee5\u524d\u306e\u30ec\u30dd\u30fc\u30c8\u3068\u4e00\u81f4\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib9\">Druzd et al\u3002\u30012017<\/a>\uff09\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u306e\u813e\u81d3\u304a\u3088\u3073\u30d1\u30a4\u30a8\u30eb\u677f\u3067\u306f\u3001T\u7d30\u80de\u6570\u306f\u8840\u6db2\u3068\u53cd\u5bfe\u306e\u5909\u5316\u3092\u793a\u3057\u3001ZT16\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001ZT4\u306b\u6700\u4e0b\u70b9\u304c\u3042\u308a\u3001\u3053\u306e\u5909\u52d5\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u5931\u308f\u308c<em>\u307e\u3057<\/em>\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig1\">\u56f31<\/a>&nbsp;G\u304a\u3088\u30731H\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304c\u30ea\u30f3\u30d1\u5668\u5b98\u3068\u672b\u68a2\u8840\u306e\u9593\u306eT\u7d30\u80de\u5206\u5e03\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306f\u3001IL-7R\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u3067GR\u30e2\u30c1\u30fc\u30d5\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066IL-7R\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u8abf\u7bc0<em>\u30a4\u30f3\u30d3\u30dc<\/em><\/h3>\n\n\n\n<p>\u4ee5\u524d\u3001GR\u304cIL-7R\u03b1\u907a\u4f1d\u5b50\u5ea7\u306e\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u3001\u4fdd\u5b58\u3055\u308c\u305f\u975e\u30b3\u30fc\u30c9\u914d\u5217\uff08CNS\uff09-1\u3092\u4ecb\u3057\u3066IL-7R\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib1\">\u963f\u90e8\u307b\u304b\u30012015\u5e74<\/a>\uff09\u3002GR\u76f4\u63a5IL-7R\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b<em>\u3001in vivo\u3067<\/em>\u3001\u6211\u3005\u306f\u3001\u4e00\u3064\u307e\u305f\u306fIL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\uff08\u5185\u306e2\u3064\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u5fdc\u7b54\u30a8\u30ec\u30e1\u30f3\u30c8\uff08GRE\uff09\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u70b9\u7a81\u7136\u5909\u7570\u3092\u4fdd\u6709\u3059\u308b\u30de\u30a6\u30b9\u3092\u751f\u6210\u3057<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u3001\u56f3S2<\/a>&nbsp;A-S2C\uff09\u3092\u3002IL-7R\u306e\u767a\u73fe\u306f\u3001IL-7R-CNS1-GRE\u5909\u7570\u30de\u30a6\u30b9\u306e\u80f8\u817aTreg\u304a\u3088\u3073\u672b\u68a2T\u7d30\u80de\u3067\u6e1b\u5c11\u3057\u307e\u3057\u305f\u304c\u3001\u4ed6\u306e\u80f8\u817a\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u3067\u306f\u6e1b\u5c11\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f32<\/a>&nbsp;A\u3001<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">S2<\/a>&nbsp;D\u2013S2F\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">S3<\/a>&nbsp;A\u2013S3D\uff09\u3002<em>Il7r&nbsp;<\/em><sup>CNS1.GRE1m \/ 1 m<\/sup>\uff08GRE1m\uff09\u304a\u3088\u3073<em>Il7r&nbsp;<\/em><sup>CNS1.GRE2m \/ 2 m<\/sup>\uff08GRE2m\uff09\u30de\u30a6\u30b9\u3067\u306f\u3001\u5358\u4e00\u30e2\u30c1\u30fc\u30d5\u306b\u5909\u7570\u304c\u3042\u308a\u3001<em>Il7r<\/em>&nbsp;mRNA\u304a\u3088\u3073\u7d30\u80de\u8868\u9762IL-7R\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u304c\u3001<em>Il7r&nbsp;<\/em><sup>CNS1.GRE12m \/ 12 m<\/sup>\uff08GRE12m\uff09\u4e21\u65b9\u306e\u30e2\u30c1\u30fc\u30d5\u306b\u5909\u7570\u304c\u3042\u308b\u30de\u30a6\u30b9\u306f\u3001\u3088\u308a\u6df1\u523b\u306a\u6e1b\u5c11\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u5b9f\u884c\u3057\u3066\u3001\u65e5\u4e2d\u306eT\u7d30\u80de\u3067\u306eIL-7R\u767a\u73fe\u306e\u5909\u5316\u3092\u3055\u3089\u306b\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002IL-7R\u306e\u767a\u73fe\u306f\u65e5\u5468\u671f\u3067\u5909\u5316\u3057\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u3067\u306fZT16\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u3001ZT4\u306b\u6700\u4e0b\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\u304c\u3001GRE12m\u30de\u30a6\u30b9\u3067\u306f1\u65e5\u3092\u901a\u3057\u3066\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f3<\/a>2B\uff09\u3002IL-7R\u03b1mRNA\u306e\u30ec\u30d9\u30eb\u3082\u540c\u69d8\u306e\u65e5\u5909\u5316\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f3<\/a>2C\uff09\u3002\u6b21\u306b\u3001\u30af\u30ed\u30de\u30c1\u30f3\u514d\u75ab\u6c88\u964d\uff08ChIP\uff09\u30a2\u30c3\u30bb\u30a4\u3092\u5b9f\u884c\u3057\u3066\u3001GR\u304c\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067CNS-1\u306b\u7d50\u5408\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002WT\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u3067\u306f\u591c\u9593\u306b\u306e\u307f\u7279\u7570\u7684GR\u7d50\u5408\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u304c\u3001GRE12m\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u3067\u306f\u3053\u306e\u7d50\u5408\u304c\u5b8c\u5168\u306b\u5931\u308f\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f3<\/a>2D\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/5bd4d297-64ec-48cc-905a-c4b65e2aead5\/gr2.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr2\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>2GR\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u306f\u3001T\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u3092\u8abf\u7bc0\u3057\u307e\u3059<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/5bd4d297-64ec-48cc-905a-c4b65e2aead5\/gr2.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/7c81939b-b8c6-462e-8626-ef11201e4249\/gr2_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr2.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<p>\u6b21\u306b\u3001invivo<em>\u3067<\/em>GR\u304c\u8a98\u5c0e\u3059\u308bIL-7R\u306e\u6a5f\u80fd\u3092\u89e3\u660e\u3057\u3088\u3046\u3068\u3057\u305f\u3002GRE12m\u30de\u30a6\u30b9\u306e\u8868\u73fe\u578b\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306e\u8868\u73fe\u578b\u3068\u985e\u4f3c\u3057\u3066\u3044\u305f\u3001\u3059\u306a\u308f\u3061\u3001\u30ea\u30f3\u30d1\u7d44\u7e54\u3068\u672b\u68a2\u8840\u306e\u9593\u306eT\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u3092\u6b20\u3044\u3066\u3044\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f32<\/a>&nbsp;E\u20132H\uff09\u3002IL-7R\u304cT\u7d30\u80de\u306e\u65e5\u5468\u518d\u5206\u5e03\u3092\u5236\u5fa1\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001T\u7d30\u80de\u7279\u7570\u7684IL-7R\u6b20\u640d\uff08<em>Il7r&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\uff09\u30de\u30a6\u30b9\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30de\u30a6\u30b9\u306f\u5bfe\u7167\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066T\u7d30\u80de\u6570\u306e\u6df1\u523b\u306a\u6e1b\u5c11\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001T\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u306f\u5931\u308f\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S3<\/a>E\u2013S3G\uff09\u3002\u3053\u308c\u3089\u306e\u767a\u898b\u306f\u3001GR\u304cIL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306eGRE\u306b\u76f4\u63a5\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066IL-7R\u767a\u73fe\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u4ee5\u524d\u306e\u7814\u7a76\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308bIL-7R\u306e\u767a\u73fe\u304c\u3001\u30ea\u30f3\u30d1\u7d44\u7e54\u3068\u672b\u68a2\u8840\u306e\u9593\u306eT\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5185\u5909\u5316\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306fIL-7R\u304a\u3088\u3073Bcl2\u306e\u767a\u73fe\u3092\u4ecb\u3057\u3066T\u7d30\u80de\u306e\u751f\u5b58\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/h3>\n\n\n\n<p>IL-7R\u306e\u6e1b\u5c11\u304cT\u7d30\u80de\u306e\u751f\u5b58\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u307e\u305a\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3092IL-7\u3068\u3068\u3082\u306b6\u65e5\u9593\u57f9\u990a\u3057\u307e\u3057\u305f\u3002IL-7\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u3088\u308a\u3082\u5c11\u306a\u3044T\u7d30\u80de\u3092<em>\u30ec\u30b9\u30ad\u30e5\u30fc\u3057\u307e\u3057<\/em>\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S4<\/a>&nbsp;A\u304a\u3088\u3073S4B\uff09\u3002T\u7d30\u80de\u306e\u751f\u5b58\u304cinvivo\u3067\u640d\u306a\u308f<em>\u308c\u305f<\/em>\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001CD45.1&nbsp;<sup>+<\/sup>\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09\u304a\u3088\u3073CD45.2&nbsp;<sup>+<\/sup>\uff08<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u307e\u305f\u306fGRE12m\uff09\u30ca\u30a4\u30fc\u30d6CD4 T\u7d30\u80de\u3092CFSE\u3067\u6a19\u8b58\u3057\u3001\u6df7\u5408\u3057\u3066\u79fb\u3057\u307e\u3057\u305f\u3002 CD45.2&nbsp;<sup>+\u306b<\/sup>C57BL \/ 6\u30de\u30a6\u30b9\u30028\u65e5\u5f8c\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u3068GRE12m\u30de\u30a6\u30b9\u306e\u9593\u3067\u3001\u813e\u81d3\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u672b\u68a2\u8840\u306eT\u7d30\u80de\u306e\u983b\u5ea6\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002GRE12m T\u7d30\u80de\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30ebT\u7d30\u80de\u3088\u308a\u3082\u8c4a\u5bcc\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S4<\/a>&nbsp;C\u304a\u3088\u3073S4D\uff09\u3002\u3055\u3089\u306b\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u8868\u73fe\u578b\u306f\u3001<em>GRE12mT<\/em>\u7d30\u80de\u306e\u8868\u73fe\u578b\u3088\u308a\u3082\u91cd\u75c7\u3067\u3057\u305f\u3002\u6b21\u306b\u3001T\u7d30\u80de\u304c\u65e5\u4e2d\u306b\u9ad8\u3044\u5272\u5408\u3067\u6b7b\u306c\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u7d30\u80de\u6b7b\u306e\u6307\u6a19\u3067\u3042\u308b\u6d3b\u6027\u5316\u30ab\u30b9\u30d1\u30fc\u30bc3\u306e\u30ec\u30d9\u30eb\u3092\u65b0\u305f\u306b\u5358\u96e2\u3057\u305f\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u306eCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306f\u3001\u591c\u9593\u3088\u308a\u3082\u663c\u9593\u306b\u9ad8\u30ec\u30d9\u30eb\u306e\u6d3b\u6027\u5316\u30ab\u30b9\u30d1\u30fc\u30bc3\u3092\u542b\u3093\u3067\u3044\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S4<\/a>E\uff09\u3002\u6b21\u306b\u3001\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u56e0\u5b50Bcl2\u304a\u3088\u3073BclxL\u306e\u767a\u73fe\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306f\u3001\u672b\u68a2T\u7d30\u80de\u304a\u3088\u3073\u80f8\u817a\u7d30\u80de\u3067Bcl2\u304a\u3088\u3073BclxL\u306e\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u3092\u767a\u73fe\u3057\u307e\u3057\u305f\u304c\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S4<\/a>&nbsp;F\u2013S4H\uff09\u3001GRE12m\u30de\u30a6\u30b9\u306f\u767a\u73fe\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S4<\/a>&nbsp;I\u2013S4K\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304cIL-7R\u4f9d\u5b58\u6027\u7d4c\u8def\u3068\u975e\u4f9d\u5b58\u6027\u7d4c\u8def\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066T\u7d30\u80de\u306e\u751f\u5b58\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30c7\u30fc\u30bf\u306f\u3001T\u7d30\u80de\u306e\u751f\u5b58\u969c\u5bb3\u304cGRE12m\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u632f\u52d5\u306e\u969c\u5bb3\u306b\u4f55\u3089\u304b\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001Bcl2\u304a\u3088\u3073BclxL\u306e\u767a\u73fe\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306e\u80f8\u817a\u7d30\u80de\u3067\u6e1b\u5c11\u3057\u307e\u3057\u305f\u304c\u3001\u305d\u308c\u3089\u306e\u7d30\u80de\u6570\u306f\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S1D\u2013S1H\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u3068IL-7R\u306f\u3001CXCR4\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308aT\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/h3>\n\n\n\n<p>\u6b21\u306b\u3001T\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u3088\u3046\u3068\u3057\u307e\u3057\u305f\u3002CXCR4\u304c\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3068IL-7\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u3068\u3044\u3046\u4ee5\u524d\u306e\u5831\u544a\u306b\u7167\u3089\u3057\u3066\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30c7\u30a3\u30df\u30c8\u30ed\u30d5\u4ed6\u30012009\u5e74<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Jourdan et al\u3002\u30012000<\/a>\uff09\u3001\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3067\u306e2\u3064\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53CXCR4\u3068CCR7\u306e\u767a\u73fe\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u307e\u3057\u305f\u3002CCR7\u306e\u767a\u73fe\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S5A&nbsp;\uff09\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u306eCD4&nbsp;<sup>+<\/sup>\u304a\u3088\u3073CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u306f\u3001CXCR4\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073mRNA\u306e\u30ec\u30d9\u30eb\u304c\u591c\u9593\u306b\u9ad8\u304f\u3001\u65e5\u4e2d\u306b\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig3\">\u56f33<\/a>&nbsp;A\u20133F\uff09\u3002\u5bfe\u7167\u7684\u306b\u3001CXCR4 mRNA\u306e\u591c\u9593\u30ec\u30d9\u30eb\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u6e1b\u5c11\u3057\u3001CXCR4\u767a\u73fe\u306e\u65e5\u5185\u5909\u52d5\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4-cre&nbsp;<\/em><sup>+\u3067<\/sup>\u5931\u308f\u308c\u307e\u3057\u305f\u3002<sup><\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3002CXCR4\u767a\u73fe\u306e\u65e5\u5909\u5316\u304cT\u7d30\u80de\u306e\u904a\u8d70\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u30b1\u30e2\u30ab\u30a4\u30f3CXCL12\u3092\u4f7f\u7528\u3057\u3066\u30c8\u30e9\u30f3\u30b9\u30a6\u30a7\u30eb\u904a\u8d70\u30a2\u30c3\u30bb\u30a4\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u3067\u306f\u3001\u591c\u9593\u306b\u5206\u96e2\u3055\u308c\u305fT\u7d30\u80de\u306f\u65e5\u4e2d\u306b\u5206\u96e2\u3055\u308c\u305f\u3082\u306e\u3088\u308a\u3082\u52b9\u7387\u7684\u306b\u79fb\u52d5\u3057\u307e\u3057\u305f\u304c\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig3\">\u56f33<\/a>&nbsp;G\u304a\u3088\u30733H\uff09\u3001\u3053\u306e\u9055\u3044\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4-cre&nbsp;<\/em><sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u306f\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001CXCR4\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u591c\u9593\u306bT\u7d30\u80de\u306e\u813e\u81d3\u3078\u306e\u30db\u30fc\u30df\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/ea2329f0-4c4c-4939-a740-c803820a3157\/gr3.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr3\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>3GR\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u306f\u3001CXCR4\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308aT\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u3092\u5236\u5fa1\u3057\u307e\u3059<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/ea2329f0-4c4c-4939-a740-c803820a3157\/gr3.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/4e8e4b2f-3ae2-40f0-8d73-31ddd1def71a\/gr3_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr3.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<p>\u813e\u81d3\u3078\u306eT\u7d30\u80de\u30db\u30fc\u30df\u30f3\u30b0\u304c\u5909\u7570\u30de\u30a6\u30b9\u3067\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001CD45.1&nbsp;<sup>+<\/sup>\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09\u3068CD45.2&nbsp;<sup>+<\/sup>\uff08<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u307e\u305f\u306fGRE12m\uff09CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092\u6df7\u5408\u3057\u3001CFSE\u3067\u6a19\u8b58\u3057\u307e\u3057\u305f\u3002\u663c\u9593\u307e\u305f\u306f\u591c\u9593\u306b\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u30de\u30a6\u30b9\u306b\u79fb\u3057\u307e\u3057\u305f\u3002T\u7d30\u80de\u304c\u591c\u9593\u306b\u79fb\u5165\u3055\u308c\u308b\u3068\u3001\u813e\u81d3\u306e\u5909\u7570T\u7d30\u80de\u306e\u983b\u5ea6\u306f\u5bfe\u7167T\u7d30\u80de\u3068\u6bd4\u8f03\u3057\u3066\u6e1b\u5c11\u3057\u307e\u3057\u305f\u304c\u3001\u672b\u68a2\u8840\u306e\u983b\u5ea6\u306f\u4e0a\u6607\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig3\">\u56f3<\/a>3I\u304a\u3088\u30733J\uff09\u3002\u7d30\u80de\u304c\u65e5\u4e2d\u306b\u79fb\u3055\u308c\u305f\u3068\u304d\u3001\u3053\u306e\u52b9\u679c\u306f\u89b3\u5bdf\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6b21\u306b\u3001CXCR4\u304cT\u7d30\u80de\u306e\u518d\u5206\u5e03\u3092\u5236\u5fa1\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001T\u7d30\u80de\u7279\u7570\u7684\u306aCXCR4\u6b20\u640d\uff08<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl<\/sup>\uff09\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002<sup><\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\uff09\u30de\u30a6\u30b9\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u3068\u306f\u7570\u306a\u308a\u3001<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306f\u3001\u8840\u6db2\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u304a\u3088\u3073\u813e\u81d3\u306eT\u7d30\u80de\u6570\u306e\u65e5\u5185\u5909\u5316\u3092\u6b20\u3044\u3066\u3044\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig3\">\u56f33<\/a>&nbsp;K\u20133M\uff09\u3002\u8840\u4e2d\u306eT\u7d30\u80de\u6570\u306f\u3001<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u3088\u308a\u9ad8\u3044\u30ec\u30d9\u30eb\u306b\u4fdd\u305f\u308c\u3066\u304a\u308a\u3001\u30db\u30fc\u30df\u30f3\u30b0\u306e\u969c\u5bb3\u3060\u3051\u3067\u306f\u7d30\u80de\u306e\u751f\u5b58\u7387\u304c\u4f4e\u4e0b\u3057\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u4ee5\u5916\u306e\u5834\u5408\u3001CD127\u304a\u3088\u3073Bcl2\u306e\u767a\u73fe\u307e\u305f\u306f<em>in vivo\u3067\u306e<\/em>\u751f\u5b58\u306b\u95a2\u3057\u3066\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u9593\u306b\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S5<\/a><em><\/em><a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\"><\/a>B\u2013S5D\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308bIL-7R\u304cCXCR4\u306e\u767a\u73fe\u3092\u65e5\u5185\u306b\u8abf\u7bc0\u3057\u3001CXCR4\u304c\u30ea\u30f3\u30d1\u5668\u5b98\u3068\u8840\u6db2\u306e\u9593\u306eT\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u6b21\u306b<em>\u3001\u30a4\u30f3\u30d3\u30dc<\/em>\u3067\u306e\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u6295\u4e0e\u304c\u3001T\u7d30\u80de\u306b\u304a\u3051\u308bIL-7R\u304a\u3088\u3073CXCR4\u306e\u767a\u73fe\u304a\u3088\u3073\u813e\u81d3\u306b\u304a\u3051\u308b\u305d\u308c\u3089\u306e\u84c4\u7a4d\u3092\u8a98\u5c0e\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8a66\u9a13\u3057\u305f\u3002IL-7R\u306e\u767a\u73fe\u306f\u3001ZT4\u3067\u306e\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u6ce8\u5c04\u306e4\u6642\u9593\u5f8c\u306bCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u4e0a\u6607\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S5E&nbsp;\uff09\u3002\u540c\u6642\u306b\u3001CXCR4\u306fCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u8a98\u5c0e\u3055\u308c\u307e\u3057\u305f\u3002CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u6570\u3082\u813e\u81d3\u3067\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5916\u56e0\u6027\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304cIL-7R\u304a\u3088\u3073CXCR4\u767a\u73fe\u306e\u8a98\u5c0e\u3068\u3001\u813e\u81d3\u3068\u8840\u6db2\u306e\u9593\u306eT\u7d30\u80de\u306e\u518d\u5206\u5e03\u3092\u518d\u73fe\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001IL-7\u306e\u5358\u72ec\u6295\u4e0e<em>\u306f\u3001invivo<\/em>\u3067\u3082<em>invitro<\/em>\u3067\u3082\u3001CD4&nbsp;<sup>+\u306e<\/sup>CXCR4\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u3002<sup><\/sup>T\u7d30\u80de\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S5<\/a>&nbsp;F\u304a\u3088\u3073S5G\uff09\u306f\u3001CXCR4\u306e\u767a\u73fe\u306bIL-7\u304c\u5fc5\u8981\u3067\u3042\u308b\u304c\u3001\u5341\u5206\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306fCXCL12\u7523\u751f\u7d30\u80de\u3078\u306eT\u7d30\u80de\u30db\u30fc\u30df\u30f3\u30b0\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/h3>\n\n\n\n<p>CXCR4\u306fT\u7d30\u80de\u904a\u8d70\u306e\u65e5\u5468\u671f\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u306fIL-7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u4f9d\u5b58\u3059\u308b\u305f\u3081\u3001\u6b21\u306b\u3001GR\u304c\u813e\u81d3\u304a\u3088\u3073\u30d1\u30a4\u30a8\u30eb\u677f\u306eCXCL12\u304a\u3088\u3073IL-7\u7523\u751f\u7d30\u80de\u306e\u8fd1\u304f\u3067T\u7d30\u80de\u904a\u8d70\u3092\u5236\u5fa1\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u813e\u81d3\u3067\u306f\u3001CXCL12\u306f\u8d64\u813e\u9ac4\u304a\u3088\u3073T\u7d30\u80de\u30be\u30fc\u30f3\u3068B\u7d30\u80de\u30be\u30fc\u30f3\u306e\u8840\u7ba1\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u3067\u5f37\u304f\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig4\">\u56f3<\/a>4A\u304a\u3088\u30734B\uff09\u3002\u4e88\u60f3\u901a\u308a\u3001\u30c9\u30ca\u30fcT\u7d30\u80de\u306f\u3001CXCL12\u767a\u73fe\u9818\u57df\u3001\u8d64\u813e\u9ac4\u3001\u304a\u3088\u3073\u8840\u7ba1\u306e\u5468\u56f2\u306b\u84c4\u7a4d\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001IL-7\u767a\u73fe\u7d30\u80de\u306fT\u7d30\u80de\u30be\u30fc\u30f3\u3068\u8840\u7ba1\u306e\u5468\u56f2\u306b\u6563\u5728\u3057\u3066\u3044\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig4\">\u56f3<\/a>4C\u304a\u3088\u30734D\uff09\u3002T\u7d30\u80de\u306f\u3001T\u7d30\u80de\u30be\u30fc\u30f3\u3068B\u7d30\u80de\u30be\u30fc\u30f3\u3067IL-7\u767a\u73fe\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u8840\u7ba1\u306e\u5468\u56f2\u306b\u5c40\u5728\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3057\u305f\u3002T\u7d30\u80de\u306e\u30db\u30fc\u30df\u30f3\u30b0\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304a\u3088\u3073<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u3092\u7570\u306a\u308b\u8272\u7d20\u3067\u6a19\u8b58\u3057\u30011\uff1a1\u3067\u6df7\u5408\u3057\u3001<em>Cxcl12<\/em>&nbsp;-GFP\u30de\u30a6\u30b9\u306b\u79fb\u3057\u307e\u3057\u305f\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u3088\u308a\u3082\u3001CXCL12&nbsp;<sup>+<\/sup>\u7d30\u80de\u306e\u8fd1\u304f\u306b\u983b\u7e41\u306b\u5c40\u5728\u3057\u3066\u3044\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig4\">\u56f3<\/a>4E\u304a\u3088\u30734F\uff09\u3002\u30d1\u30a4\u30a8\u30eb\u677f\u3067\u306f\u3001T\u7d30\u80de\u30be\u30fc\u30f3\u5185\u304a\u3088\u3073\u305d\u306e\u5468\u8fba\u3067GFP\u30b7\u30b0\u30ca\u30eb\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S6A\u304a\u3088\u3073S6B\uff09\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u306fCXCL12&nbsp;<sup>+\u306e<\/sup>\u8fd1\u304f\u306b\u5c40\u5728\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f<em><\/em><sup><\/sup><em><\/em><sup><\/sup><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig4\"><\/a><a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\"><\/a><sup><\/sup>T\u7d30\u80de\u30be\u30fc\u30f3\u5468\u8fba\u306e\u7d30\u80de\u3002\u813e\u81d3\u306f\u5bfe\u7167\u7684\u306b\u3001\u30d1\u30a4\u30a8\u30eb\u677f\u306b\u304a\u3051\u308b\u8840\u7ba1\u306f\u3001IL-7\u767a\u73fe\u7d30\u80de\u306b\u56f2\u307e\u308c\u3066\u3044\u305f\u304c\u3001CXCL12\u306b\u3088\u308b\u3082\u306e<sup>+<\/sup>\u7d30\u80de\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S6<\/a>\u304b\u3089B\u304a\u3088\u3073S6C\uff09\u3001\u304a\u3088\u3073T\u7d30\u80de<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306f\u30d1\u30a4\u30a2\u30fc\u306b\u5c11\u306a\u3044\u79fb\u884c\u3057\u307e\u3057\u305f\u30d1\u30c3\u30c1\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S6<\/a>&nbsp;D\u304a\u3088\u3073S6E\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308bCXCR4\u767a\u73fe\u304c\u3001\u813e\u81d3\u306eCXCL12\u7523\u751f\u7d30\u80de\u3078\u306eT\u7d30\u80de\u30db\u30fc\u30df\u30f3\u30b0\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/61f94fc1-a531-44b7-ae5a-eaa152f5d882\/gr4.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr4\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>4GR\u306b\u3088\u308bCXCR4\u767a\u73fe\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306fCXCL12\u7523\u751f\u7d30\u80de\u3078\u306eT\u7d30\u80de\u904a\u8d70\u3092\u8a98\u5c0e\u3059\u308b<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/61f94fc1-a531-44b7-ae5a-eaa152f5d882\/gr4.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/6240b77e-245b-4add-a62e-ca9e3a3ef6c0\/gr4_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr4.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306f\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067IL-2\u5fdc\u7b54\u3068T\u7d30\u80de\u6d3b\u6027\u5316\u3092\u5f37\u5316\u3057\u307e\u3059<\/h3>\n\n\n\n<p>T\u7d30\u80de\u306e\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u306f\u30ea\u30f3\u30d1\u7d44\u7e54\u3067\u8d77\u3053\u308b\u305f\u3081\u3001\u591c\u9593\u306eT\u7d30\u80de\u306e\u84c4\u7a4d\u304c\u813e\u81d3\u3068\u30d1\u30a4\u30a8\u30eb\u677f\u3067\u52b9\u7387\u7684\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3057\u305f\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3068IL-7\u306fIL-2\u53d7\u5bb9\u4f53\u03b1\u9396\uff08CD25\uff09\u306e\u767a\u73fe\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u305f\u3081\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib14\">Franchimont et al\u3002\u30012002<\/a>\uff09\u3001\u6700\u521d\u306b\u6297CD3\u304a\u3088\u3073\u6297CD28\u6297\u4f53\u3067\u523a\u6fc0\u3057\u305f\u5f8c\u306eT\u7d30\u80de\u6d3b\u6027\u5316\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;CD4&nbsp;<sup>+<\/sup>\u304a\u3088\u3073CD8&nbsp;<sup>+<\/sup>&nbsp;T GRE12m T\u7d30\u80de\u306f\uff08\u3057\u306a\u304b\u3063\u305fZT4\u53ca\u3073ZT16\u3067\u5358\u96e2\u3055\u308c\u305f\u7d30\u80de\u306f\u3001\u5897\u6b96\u969c\u5bb3\u3092\u793a\u3057<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig5\">\u3001\u56f35<\/a>&nbsp;A\u53ca\u3073<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">S7<\/a>&nbsp;A\uff09\u3002\u4e00\u8cab\u3057\u3066\u3001<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;GRE12m T\u7d30\u80de\u306f\uff08\u3057\u306a\u304b\u3063\u305fT\u7d30\u80de\u306f\u3001CD25\u767a\u73fe\u304a\u3088\u3073STAT5\u306e\u30ea\u30f3\u9178\u5316\u306e\u6e1b\u5c11\u3092\u793a\u3057\u305f<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig5\">\u56f35<\/a>&nbsp;B\u30015C\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">S7<\/a>&nbsp;B\uff09\u3002\u4e00\u65b9\u3001IL-2\u53d7\u5bb9\u4f53\u03b2\u9396\uff08CD122\uff09\u306e\u767a\u73fe\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl<\/sup>\u3067\u308f\u305a\u304b\u306b\u4e0a\u6607\u3057<em>\u307e\u3057\u305f<\/em><sup><\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001IL-7R\u306e\u767a\u73fe\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001GR\u30b7\u30b0\u30ca\u30eb\u304cT\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u523a\u6fc0\u5f8c\u306eT\u7d30\u80de\u306e\u5897\u6b96\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306b\u3001\u30aa\u30dc\u30a2\u30eb\u30d6\u30df\u30f3\uff08OVA\uff09\u3092\u767a\u73fe\u3059\u308b<em>\u30ea\u30b9\u30c6\u30ea\u30a2\u83cc<\/em>\u3092\u611f\u67d3\u3055\u305b\u3001OVA\u7279\u7570\u7684CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u3067\u306f\u3001OVA\u7279\u7570\u7684CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u5272\u5408\u3068\u7d30\u80de\u6570\u306f\u3001\u30de\u30a6\u30b9\u304c\u611f\u67d3\u3057\u3001\u591c\u9593\u306b\u5206\u6790\u3055\u308c\u305f\u5834\u5408\u3001\u65e5\u4e2d\u306b\u64cd\u4f5c\u304c\u884c\u308f\u308c\u305f\u5834\u5408\u3088\u308a\u3082\u9ad8\u304b\u3063\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig5\">\u56f3<\/a>5D\u304a\u3088\u30735E\uff09\u3002\u5bfe\u7167\u7684\u306b\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u3001OVA\u7279\u7570\u7684CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u6570\u304c\u6e1b\u5c11\u3057\u3001\u65e5\u5185\u5909\u5316\u306f\u305d\u308c\u307b\u3069\u9855\u8457\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001GRE12m\u30de\u30a6\u30b9\u306f\u3001TCR\u523a\u6fc0\u5f8c\u306eT\u7d30\u80de\u5897\u6b96\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u306a\u304f\u3066\u3082\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3068\u540c\u69d8\u306e\u8868\u73fe\u578b\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig5\">\u56f3<\/a>5F\u304a\u3088\u30735G\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u3001\u7d76\u5bfe\u7d30\u80de\u6570\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306b\u52a0\u3048\u3066\u3001\u591c\u9593\u306b\u7d30\u80de\u3054\u3068\u306bCD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u5fdc\u7b54\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/da6aa101-37bf-4c8e-93c5-f7f6b8088d5c\/gr5.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr5\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>5GR\u306fT\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u5897\u6b96\u3068\u514d\u75ab\u5fdc\u7b54\u306e\u65e5\u5909\u5316\u3092\u8abf\u7bc0\u3059\u308b<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/da6aa101-37bf-4c8e-93c5-f7f6b8088d5c\/gr5.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/b6f09e20-63fe-4823-b578-8f00fa192a9b\/gr5_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr5.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306fTh\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u5316\u3068B\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u307e\u3059<\/h3>\n\n\n\n<p>\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f1\u578b\u30d8\u30eb\u30d1\u30fcT\uff08Th1\uff09\u3068Th2\u7d30\u80de\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib10\">\u30a8\u30ec\u30f3\u30b3\u30d5\u30012004\u5e74<\/a>\uff09\u3001\u6b21\u306b\u3001\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306eTh1\u7d30\u80de\u3068Th2\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09-\u03b3\u7523\u751f\u7d30\u80de\u306e\u5206\u5316\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u4e0a\u6607\u3057<em>\u307e\u3057\u305f\u304c<\/em>\u3001IL-4-\u304a\u3088\u3073IL-13\u7523\u751f\u7d30\u80de\u306e\u5206\u5316\u306f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S7C\u304a\u3088\u3073S7D\uff09\u3002\u8ee2\u5199\u56e0\u5b50E4BP4\u306f\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib40\">So et al\u3002\u30012009<\/a>\uff09\u305d\u3057\u3066Th2\u30b5\u30a4\u200b\u200b\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u67cf\u7530\u307b\u304b\u30012011\u5e74<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u672c\u6751\u307b\u304b\u30012011\u5e74<\/a>\uff09\u3002\u3053\u308c\u3068\u4e00\u81f4\u3057\u3066\u3001GATA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea3\uff08GATA3\uff09\u3067\u306f\u306a\u304fE4BP4\u306e\u767a\u73fe\u304c\u3001Th2\u7d30\u80de\u8a98\u5c0e\u6761\u4ef6\u4e0b\u3067\u57f9\u990a\u3055\u308c\u305f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3067\u6e1b\u5c11\u3057<em>\u307e\u3057\u305f<\/em>\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S7E&nbsp;\uff09\u3002\u6b21\u306b\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3092ZT16\u306eOVA\u3067\u514d\u75ab\u3057\u307e\u3057\u305f\u30027\u65e5\u5f8c\u3001\u813e\u81d3\u7d30\u80de\u3092OVA\u30673\u65e5\u9593\u523a\u6fc0\u3057\u305f\u3002IL-4\u304a\u3088\u3073IL-13\u306e<em>\u7523\u751f<\/em>\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u6709\u610f\u306b\u640d\u306a\u308f\u308c\u3001IL-4\u304a\u3088\u3073IL-13 mRNA\u306e\u30ec\u30d9\u30eb\u3082<em>Nr3c1fl&nbsp;<\/em><sup>\/ fl\u306e<\/sup>\u6ffe\u80de\u30d8\u30eb\u30d1\u30fcT\uff08Tfh\uff09\u7d30\u80de\u3067<em>\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/em><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S7<\/a>&nbsp;F\u304a\u3088\u3073S7G\uff09\u3002\u5bfe\u7167\u7684\u306b\u3001GRE12m\u30de\u30a6\u30b9\u306fTh\u7d30\u80de\u5206\u5316\u306b\u5909\u5316\u3092\u793a\u3055\u306a\u304b\u3063\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S7H&nbsp;\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304cIL-7R\u306e\u767a\u73fe\u3068\u306f\u7121\u95a2\u4fc2\u306bTh\u7d30\u80de\u306e\u5206\u5316\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u3001B\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u304c\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b<em>\u6982<\/em>\u65e5\u30ea\u30ba\u30e0\u306b\u3082\u5f93\u3046\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3092\u591c\u9593\u307e\u305f\u306f\u663c\u9593\u306bOVA\u3067\u514d\u75ab\u3057<em>\u307e\u3057\u305f<\/em>\u3002\u30a8\u30d5\u30a7\u30af\u30bf\u30fcCD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3068\u540c\u69d8\u306b\u3001\u3053\u306e\u514d\u75ab\u5316\u306b\u3088\u308a\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u3067\u306fTfh\u7d30\u80de\u3001\u80da\u4e2d\u5fc3B\u7d30\u80de\u3001\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\uff08Ig\uff09G1&nbsp;<sup>+<\/sup>&nbsp;B\u7d30\u80de\u304c\u65e5\u5468\u30ea\u30ba\u30e0\uff08\u591c\u9593\u306f\u9ad8\u304f\u3001\u663c\u9593\u306f\u4f4e\u3044\uff09\u3067\u8a98\u5c0e\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u65e5\u5468\u5909\u5316\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u969c\u5bb3\u304c\u3042\u308a\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig6\">\u56f36<\/a>&nbsp;A\u20136C\uff09\u3002\u3055\u3089\u306b\u3001NP\u7279\u7570\u7684IgG1\u304a\u3088\u3073IgG2b\u306e<em>\u7523\u751f<\/em>\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;&#8211;&nbsp;<em>cre\u3067<\/em>\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<sup>+<\/sup>\u591c\u306e\u30de\u30a6\u30b9\u3001\u304a\u3088\u3073\u65e5\u5468\u30ea\u30ba\u30e0\u304c\u5931\u308f\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig6\">\u56f3<\/a>6D\uff09\u3002Tfh\u7d30\u80de\u3001\u80da\u4e2d\u5fc3B\u7d30\u80de\u3001\u304a\u3088\u3073IgG1&nbsp;<sup>+<\/sup>&nbsp;B\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u8a98\u5c0e\u306f\u3001GRE12m\u30de\u30a6\u30b9\u3067\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S7I&nbsp;\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304cIL-7R\u306e\u767a\u73fe\u306b\u5fdc\u3058\u3066\u3001Tfh\u7d30\u80de\u3092\u4ecb\u3057\u3066\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067B\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/c1f70df7-8315-4253-872e-1b0333c5223b\/gr6.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr6\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>6GR\u306fTh\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u5316\u3068\u4f53\u6db2\u6027\u514d\u75ab\u53cd\u5fdc\u3092\u5236\u5fa1\u3057\u307e\u3059<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/c1f70df7-8315-4253-872e-1b0333c5223b\/gr6.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/cb160f4b-5ef4-4e22-9667-4138ef0e2647\/gr6_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr6.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<p>\u30d1\u30a4\u30a8\u30eb\u677f\u306f\u30ea\u30f3\u30d1\u7d44\u7e54\u3067\u3042\u308a\u3001\u514d\u75ab\u304c\u306a\u304f\u3066\u3082\u80da\u4e2d\u5fc3\u304c\u5171\u751f\u5fae\u751f\u7269\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib19\">\u539f\u7530\u307b\u304b\u30012012\u5e74<\/a>\uff09\u3002\u5bfe\u7167\u30de\u30a6\u30b9\u306e\u30d1\u30a4\u30a8\u30eb\u677f\u3067\u306f\u3001Tfh\u7d30\u80de\u3001\u80da\u4e2d\u5fc3B\u7d30\u80de\u3001\u304a\u3088\u3073IgG1&nbsp;<sup>+<\/sup>&nbsp;B\u7d30\u80de\u306e\u6570\u306f\u663c\u9593\u3068\u591c\u9593\u3067\u5909\u5316\u305b\u305a\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u305d\u308c\u3089\u306e\u6570\u304c\u6e1b\u5c11\u3057<em>\u307e\u3057<\/em>\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig6\">\u56f36<\/a>&nbsp;E\u304a\u3088\u30736F\uff09\u3002 \uff09\u3001\u4e00\u65b9\u3001GRE12m\u30de\u30a6\u30b9\u306e\u3082\u306e\u306f\u305d\u308c\u307b\u3069\u660e\u78ba\u306a\u6e1b\u5c11\u3092\u793a\u3055\u306a\u304b\u3063\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3<\/a>S7J&nbsp;\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u304cIL-7R\u306e\u767a\u73fe\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001T\u7d30\u80de\u3092\u4ecb\u3057\u305fB\u7d30\u80de\u5fdc\u7b54\u306b\u5bdb\u5bb9\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;GR\u306fIL-7R\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30e2\u30ea\u30fcCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u7dad\u6301\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059<\/h3>\n\n\n\n<p>IL-7R\u306f\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u3067\u3088\u308a\u9ad8\u3044\u30ec\u30d9\u30eb\u3067\u767a\u73fe\u3055\u308c\u3001\u305d\u308c\u3089\u306e\u751f\u5b58\u306b\u91cd\u8981\u3067\u3042\u308b\u305f\u3081\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Kondrack et al\u3002\u30012003<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Schluns et al\u3002\u30012000<\/a>\uff09\u3001\u6b21\u306b\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u30e1\u30e2\u30ea\u30fcCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306b\u304a\u3051\u308bIL-7R\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u306fTh2\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u990a\u5b50\u79fb\u5165\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u3066\u30e1\u30e2\u30ea\u30fcTh2\u7d30\u80de\u3092\u751f\u6210\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib11\">\u9060\u85e4\u307b\u304b\u30012011\u5e74<\/a>\uff09\u3002\u307e\u305a\u3001\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3092Th2\u7d30\u80de\u6761\u4ef6\u4e0b\u30676\u65e5\u9593\u57f9\u990a\u3057\u305f\u5f8c\u3001\u30a8\u30d5\u30a7\u30af\u30bf\u30fcT\u7d30\u80de\u3092B6.CD45.1&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306b\u79fb\u3057\u307e\u3057\u305f\u30024\u9031\u9593\u5f8c\u3001\u813e\u81d3\u306eCD45.2&nbsp;<sup>+<\/sup>\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306b\u304a\u3051\u308bIL-7R\u767a\u73fe\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3068\u540c\u69d8\u306b\u3001IL-7R\u767a\u73fe\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7d30\u80de\u3068\u6bd4\u8f03\u3057\u3066\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u3067\u6e1b\u5c11\u3057<em>\u307e\u3057\u305f<\/em>\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig7\">\u56f3<\/a>7A\u304a\u3088\u30737B\uff09\u3002\u3055\u3089\u306b\u3001IL-7R\u767a\u73fe\u306e\u65e5\u5185\u5909\u5316\u306f\u5909\u7570\u4f53\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u3067\u5931\u308f\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig7\">\u56f3<\/a>7C\uff09\u3002\u6570<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u3068GRE12m\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306f\u813e\u81d3\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u53ca\u3073\u80ba\u306b\u304a\u3044\u3066\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u7d30\u80de\u306f\u3001GRE12m\u7d30\u80de\u3088\u308a\u3082\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig7\">\u56f3<\/a>7D\uff09\u3002\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3068\u540c\u69d8\u306b\u3001Bcl-2\u306e\u767a\u73fe\u306f<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u7d30\u80de\u3067\u306f\u6e1b\u5c11\u3057<em>\u307e\u3057\u305f<\/em>\u304c\u3001GRE12m\u7d30\u80de\u3067\u306f\u6e1b\u5c11\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig7\">\u56f3<\/a>7E\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GR\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u304c\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306e\u7dad\u6301\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/8e239d08-ff2c-4966-beeb-ebf28185d17a\/gr7.jpg?w=640&#038;ssl=1\" alt=\"\u56f3\u30b5\u30e0\u30cd\u30a4\u30ebgr7\" data-recalc-dims=\"1\"\/><figcaption><strong>\u56f3<\/strong>7GR\u306f\u3001IL-7R\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30e1\u30e2\u30ea\u30fcCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u7dad\u6301\u3092\u30b5\u30dd\u30fc\u30c8\u3057<strong>\u307e\u3059<\/strong><sup><\/sup><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30ad\u30e3\u30d7\u30b7\u30e7\u30f3\u5168\u4f53\u3092\u8868\u793a<\/a><a target=\"_blank\" href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/8e239d08-ff2c-4966-beeb-ebf28185d17a\/gr7.jpg\" rel=\"noreferrer noopener\">\u5927\u304d\u306a\u753b\u50cf\u3092\u8868\u793a<\/a><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30a3\u30ae\u30e5\u30a2\u30d3\u30e5\u30fc\u30a2<\/a><a href=\"https:\/\/els-jbs-prod-cdn.jbs.elsevierhealth.com\/cms\/attachment\/4329ab0f-f711-459c-9b04-ec956c8d35db\/gr7_lrg.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><a href=\"https:\/\/www.cell.com\/action\/downloadFigures?pii=S1074-7613(18)30004-9&amp;id=gr7.jpg\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff08PPT\uff09<\/a><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0080\">\u8a0e\u8ad6<\/h2>\n\n\n\n<p>\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u306f\u5f37\u529b\u306a\u6297\u708e\u75c7\u4f5c\u7528\u3068\u514d\u75ab\u6291\u5236\u4f5c\u7528\u304c\u3042\u308b\u3068\u3044\u3046\u9577\u5e74\u306e\u898b\u89e3\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u3053\u306e\u7814\u7a76\u306f\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u514d\u75ab\u5897\u5f37\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3068GR\u306f\u3001IL-7R\u03b1\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u3067\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067IL-7R\u306e\u767a\u73fe\u3092\u76f4\u63a5\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u4e0a\u6607\u3057\u305fIL-7R\u306f\u3001CXCR4\u306e\u767a\u73fe\u3092\u4ecb\u3057\u3066\u672b\u68a2\u30ea\u30f3\u30d1\u5668\u5b98\u3078\u306eT\u7d30\u80de\u306e\u30db\u30fc\u30df\u30f3\u30b0\u3092\u8a98\u5c0e\u3057\u3001\u30de\u30a6\u30b9\u306e\u591c\u9593\u306eT\u7d30\u80de\u3068B\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u5897\u5f37\u3057\u307e\u3059\u3002GRE12m\u30de\u30a6\u30b9\u306e\u4f7f\u7528\u306f\u3001\u3053\u306e\u7406\u89e3\u306b\u5c0e\u304f\u4e0a\u3067\u975e\u5e38\u306b\u91cd\u8981\u3067\u3057\u305f\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u3088\u308bT\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u306f\u3001\u5e83\u7bc4\u56f2\u306eT\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u306e\u518d\u5faa\u74b0\u3068\u9577\u671f\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u30d2\u30c8T\u7d30\u80de\u3067\u3082IL-7R\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u3067\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib14\">Franchimont et al\u3002\u30012002<\/a>\uff09\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u3053\u306e\u514d\u75ab\u5897\u5f37\u6a5f\u80fd\u306f\u3001\u30d2\u30c8\u3067\u3082\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6211\u3005\u306e\u767a\u898b\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3068IL-7\u304cT\u7d30\u80de\u306e\u751f\u5b58\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u304c\u3001\u7d30\u80de\u306e\u751f\u5b58\u304cT\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u306b\u5bc4\u4e0e\u3059\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u306f\u3069\u306e\u3088\u3046\u306b\u5bc4\u4e0e\u3059\u308b\u304b\u306f\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\u3002<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u306f\u3001T\u7d30\u80de\u306e\u751f\u5b58\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u5909\u7570\u30de\u30a6\u30b9\u306eT\u7d30\u80de\u6570\u306e\u632f\u52d5\u306e\u969c\u5bb3\u306b\u4f55\u3089\u304b\u306e\u5f79\u5272\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306f\u3001\u751f\u5b58\u306b\u6b20\u9665\u304c\u306a\u304f\u3001T\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u306e\u5b9f\u8cea\u7684\u306a\u969c\u5bb3\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30db\u30fc\u30df\u30f3\u30b0\u306e\u969c\u5bb3\u3060\u3051\u3067\u306f\u3001\u5fc5\u305a\u3057\u3082\u8840\u4e2d\u306e\u7d30\u80de\u6570\u304c\u6e1b\u5c11\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001CXCR4\u306e\u767a\u73fe\u306f\u3001\u7d30\u80de\u306e\u751f\u5b58\u3088\u308a\u3082\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u306b\u304a\u3044\u3066\u3088\u308a\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u8abf\u67fb\u7d50\u679c\u306f\u3001\u514d\u75ab\u7cfb\u306e\u6982\u65e5\u5909\u5316\u306b\u95a2\u3057\u3066\u91cd\u8981\u306a\u610f\u5473\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u8840\u4e2d\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u30ec\u30d9\u30eb\u306f\u3001\u602a\u6211\u3084\u611f\u67d3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u65e5\u5e38\u751f\u6d3b\u306e\u6d3b\u52d5\u671f\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u7d50\u679c\u3068\u3057\u3066\u751f\u3058\u308b\u813e\u81d3\u3078\u306eT\u7d30\u80de\u306e\u84c4\u7a4d\u306f\u3001\u4fb5\u5165\u3059\u308b\u5fae\u751f\u7269\u3068\u6226\u3046\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u308c\u3068\u4e00\u81f4\u3057\u3066\u3001\u514d\u75ab\u7cfb\u306f\u65e5\u5468\u30ea\u30ba\u30e0\u306e\u5236\u5fa1\u4e0b\u306b\u3042\u308a\u307e\u3059\u3002\u4ee5\u524d\u306e\u7814\u7a76\u3067\u306f\u3001\u81ea\u7136\u514d\u75ab\u7d30\u80de\u304c\u591c\u9593\u306e\u7d30\u83cc\u611f\u67d3\u306b\u52b9\u7387\u7684\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib7\">Curtis et al\u3002\u30012014<\/a>\uff09\u3002\u6982\u65e5CXCL12\u306e\u767a\u73fe\u306f\u3001\u8001\u5316\u3057\u305f\u597d\u4e2d\u7403\u306e\u9aa8\u9ac4\u3078\u306e\u79fb\u52d5\u3068\u3001\u7d44\u7e54\u306b\u5b58\u5728\u3059\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u305d\u308c\u3089\u306e\u98f2\u307f\u8fbc\u307f\u3092\u8a98\u767a\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib4\">\u30ab\u30b5\u30ce\u30d0-\u30a8\u30fc\u30b9\u30d9\u30b9\u4ed6\u30012013\u5e74<\/a>\uff09\u3001\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u809d\u81d3X\u53d7\u5bb9\u4f53\u306f\u3001\u98df\u4f5c\u7528\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u6982\u65e5\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001Toll\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff099\u306e\u767a\u73fe\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304a\u3088\u3073B\u7d30\u80de\u306e\u5915\u66ae\u308c\u6642\u306b\u9ad8\u304f\u306a\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib39\">\u30b7\u30eb\u30d0\u30fc\u4ed6\u30012012\u5e74<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068B7\u5171\u523a\u6fc0\u5206\u5b50\u306e\u30ec\u30d9\u30eb\u306f\u3001\u813e\u81d3\u3067\u306f\u663c\u9593\u3088\u308a\u3082\u591c\u9593\u306e\u65b9\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib39\">\u30b7\u30eb\u30d0\u30fc\u4ed6\u30012012\u5e74<\/a>\uff09\u3001\u6297\u539f\u63d0\u793a\u304c\u591c\u9593\u306b\u5897\u5f37\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u30ea\u30f3\u30d1\u7bc0T\u7d30\u80de\u306e<em>invitro<\/em>\u5897\u6b96\u306f\u3001\u4e3b\u306b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u5b50ZAP-70\u306e\u767a\u73fe\u304c\u9ad8\u3044\u305f\u3081\u3001\u7d30\u80de\u304c\u65e5\u4e2d\u3088\u308a\u3082\u591c\u9593\u306b\u5358\u96e2\u3055\u308c\u305f\u5834\u5408\u306b\u901f\u304f\u306a\u308a\u307e\u3059\u304c\u3001T\u7d30\u80de\u5fdc\u7b54\u306f\u3001\u30de\u30a6\u30b9\u304c\u65e5\u4e2d\u306b\u514d\u75ab\u3055\u308c\u305f\u5834\u5408\u3088\u308a\u3082\u5f37\u304f\u306a\u308a\u307e\u3059\u591c \uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib12\">Fortier et al\u3002\u30012011<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u6642\u70b9\u306e\u3044\u304f\u3064\u304b\u306f\u3001\u813e\u81d3\u3078\u306eT\u7d30\u80de\u518d\u5206\u5e03\u306e\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u8a98\u767a\u6027\u65e5\u5468\u30ea\u30ba\u30e0\u306b\u5bfe\u5fdc\u3057\u307e\u3059\u3002\u514d\u75ab\u7cfb\u306e\u6982\u65e5\u5909\u5316\u306f\u3001\u5c11\u306a\u304f\u3068\u30823\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u307e\u3059\u3002\u7b2c\u4e00\u306b\u3001\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u795e\u7d4c\u4fe1\u53f7\u306f\u3001\u30ea\u30f3\u30d1\u7bc0\u306b\u304a\u3051\u308b\u65e5\u4e2d\u306e\u30ea\u30f3\u30d1\u7403\u518d\u5faa\u74b0\u306b\u3088\u3063\u3066\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib41\">\u9234\u6728\u307b\u304b\u30012016\u5e74<\/a>\uff09\u3002\u7b2c\u4e8c\u306b\u3001\u30ea\u30f3\u30d1\u7403\u6642\u8a08\u907a\u4f1d\u5b50<em>Arntl<\/em>\u306f\u3001CCR7\u3068S1PR1\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30ea\u30f3\u30d1\u7bc0\u3092\u901a\u904e\u3059\u308b\u8f38\u9001\u3068\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib9\">Druzd et al\u3002\u30012017<\/a>\uff09\u3002\u3053\u308c\u3089\u306e2\u3064\u306e\u7d4c\u8def\u306f\u3001\u4e3b\u306b\u672b\u68a2\u30ea\u30f3\u30d1\u7bc0\u3092\u4ecb\u3057\u305f\u30ea\u30f3\u30d1\u7403\u306e\u518d\u5faa\u74b0\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u7b2c\u4e09\u306b\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u8840\u6db2\u3068\u30ea\u30f3\u30d1\u5668\u5b98\u306e\u9593\u306eT\u7d30\u80de\u306e\u65e5\u4e2d\u306e\u518d\u5206\u5e03\u3092\u8abf\u7bc0\u3057\u3001\u813e\u81d3\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u9ad8\u3081\u307e\u3059\u3002\u4e00\u7dd2\u306b\u3001\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30ea\u30f3\u30d1\u7bc0\u3068\u813e\u81d3\u306e\u9593\u306eT\u7d30\u80de\u6570\u306e\u632f\u52d5\u306b\u6642\u9593\u7684\u306a\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3088\u308a\u8a73\u7d30\u306a\u5206\u6790\u306f\u3001\u30ea\u30f3\u30d1\u5668\u5b98\u306b\u304a\u3051\u308b\u30ea\u30f3\u30d1\u7403\u5206\u5e03\u306e\u65e5\u5909\u5316\u306e\u3088\u308a\u5305\u62ec\u7684\u306a\u30d3\u30e5\u30fc\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001IL-7R\u4f9d\u5b58\u6027\u304a\u3088\u3073\u975e\u4f9d\u5b58\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066T\u7d30\u80de\u6a5f\u80fd\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002\u6211\u3005\u306f\u3001CXCR4\u3092\u4ecb\u3057\u305f\u65e5\u4e2d\u306eT\u7d30\u80de\u306e\u518d\u5206\u5e03\u304c<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u540c\u69d8\u306b\u8abf\u7bc0\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u4e3b\u306bIL-7R\u4f9d\u5b58\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002\u5bfe\u7167\u7684\u306b\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306f\u3001\u30ca\u30a4\u30fc\u30d6T\u7d30\u80de\u3068\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306e\u751f\u5b58\u3001\u304a\u3088\u3073CD8&nbsp;<sup>+\u306e<\/sup>\u514d\u75ab\u5fdc\u7b54\u306b\u95a2\u3057\u3066\u3001\u3088\u308a\u6df1\u523b\u306a\u8868\u73fe\u578b\u3092\u793a\u3057\u307e\u3057\u305f\u3002<sup><\/sup>GRE12m\u30de\u30a6\u30b9\u3088\u308a\u3082T\u7d30\u80de\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u304a\u305d\u3089\u304fIL-7R\u4f9d\u5b58\u6027\u3068\u975e\u4f9d\u5b58\u6027\u306e\u4e21\u65b9\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u3053\u308c\u3089\u306e\u514d\u75ab\u6a5f\u80fd\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u6700\u5f8c\u306b\u3001Th\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u5316\u3068B\u7d30\u80de\u514d\u75ab\u5fdc\u7b54\u306f\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u304a\u3088\u3073GRE12m\u30de\u30a6\u30b9\u3067\u640d\u306a\u308f\u308c\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u4e3b\u306bIL-7R\u4f9d\u5b58\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u3066\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002GR\u306f\u3001<em>Nfil3<\/em>\u306a\u3069\u306e\u4ed6\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u307e\u305f\u306f\u4ed6\u306e\u8ee2\u5199\u56e0\u5b50\u3068\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001IL-7R\u306b\u4f9d\u5b58\u3057\u306a\u3044\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002GR\u306f\u3001\u8907\u6570\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067Th\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u5316\u3068\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002\u6211\u3005\u306e\u767a\u898b\u306f\u3001GR\u304cTh2\u30b5\u30a4\u200b\u200b\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3068B\u7d30\u80de\u514d\u75ab\u5fdc\u7b54\u3092\u5897\u5f37\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001GR\u306fTh1\u7d30\u80de\u306e\u5206\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001AP-1\u3001NF-\u03baB\u3001NFAT\u306a\u3069\u306e\u8ee2\u5199\u56e0\u5b50\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066Th1\u7d30\u80de\u306e\u5206\u5316\u3092\u963b\u5bb3\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib3\">Ashwell et al\u3002\u30012000<\/a>\uff09\u307e\u305f\u3001STAT4\u304a\u3088\u3073T\u30dc\u30c3\u30af\u30b9\u8ee2\u5199\u56e0\u5b5021\uff08TBX21\uff09\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Franchimont et al\u3002\u30012000<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Liberman et al\u3002\u30012007<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u6211\u3005\u306e\u7d50\u679c\u306f\u3001E4BP4\u306e\u767a\u73fe\u304c<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u3067\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002E4BP4\u306fIL-4\u304a\u3088\u3073IL-13\u7523\u751f\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u3067\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib25\">\u67cf\u7530\u307b\u304b\u30012011\u5e74<\/a>\uff09\u3001\u304a\u3088\u3073GR\u306f\u305d\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066<em>Nfil3<\/em>\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u8a98\u5c0e\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib40\">So et al\u3002\u30012009<\/a>\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6211\u3005\u306e\u767a\u898b\u306f\u3001GR\u304cE4BP4\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066IL-4\u304a\u3088\u3073IL-13\u306e\u7523\u751f\u3092\u5897\u5f37\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u306e\u3067<em>NFIL3\u306f\u3001<\/em>\u6642\u8a08\u907a\u4f1d\u5b50\u305d\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u306f\u591c\u9593\u9ad8\u304f\u3001GR-E4BP4\u8ef8\u306f\u3001Th2\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u306e\u65e5\u5909\u5316\u306e\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3055\u3089\u306b\u3001GR\u304c\u65e5\u4e2d\u306eIL-7R\u8a98\u5c0e\u3092\u4ecb\u3057\u3066\u8a18\u61b6Th2\u7d30\u80de\u306e\u751f\u5b58\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002IL-7\u30b7\u30b0\u30ca\u30eb\u306fTh2\u30b5\u30a4\u200b\u200b\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u3092\u52a9\u3051\u308b\u305f\u3081\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib17\">Guo et al\u3002\u30012015<\/a>\uff09\u3001GR\u306fTh2\u7d30\u80de\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3001\u30df\u30cd\u30e9\u30eb\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306a\u3069\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306f\u3001\u514d\u75ab\u7cfb\u306b\u5f37\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3060\u3051\u3067\u306a\u304f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u3084\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3082\u526f\u814e\u76ae\u8cea\u304b\u3089\u65e5\u4e2d\u306e\u65b9\u6cd5\u3067\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304cIL-7R\u306e\u767a\u73fe\u3068\u30ea\u30f3\u30d1\u5668\u5b98\u3078\u306eT\u7d30\u80de\u306e\u518d\u5206\u5e03\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u3068B\u7d30\u80de\u306e\u5fdc\u7b54\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u306f\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304cTh1\u7d30\u80de\u306e\u5206\u5316\u3092\u9632\u304e\u3001Th2\u7d30\u80de\u306e\u5206\u5316\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u52a0\u3048\u3066\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306fTh1\u7d30\u80de\u306e\u5206\u5316\u3092\u963b\u5bb3\u3057\u307e\u3059\u304c\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306fIFN-\u03b3\u3068IL-10\u306e\u7523\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Gilmore et al\u3002\u30011997<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Kissick et al\u3002\u30012014<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u5bae\u6d66\u30fb\u5ca9\u7530\u30012002<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u5f71\u97ff\u306f\u6982\u65e5\u5468\u671f\u306e\u5236\u5fa1\u4e0b\u306b\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u6b21\u306b\u3001\u5598\u606f\u304a\u3088\u3073\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u75c7\u72b6\u304c\u671d\u306b\u60aa\u5316\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3068\u3044\u3046\u89b3\u5bdf\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u514d\u75ab\u306e\u591a\u304f\u306e\u5074\u9762\u304c\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u5236\u5fa1\u4e0b\u306b\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5c06\u6765\u306e\u7814\u7a76\u3067\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u89b3\u70b9\u304b\u3089\u514d\u75ab\u5b66\u7684\u73fe\u8c61\u3092\u89e3\u6c7a\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u7c98\u819c\u514d\u75ab\u3092\u5236\u5fa1\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002GR-IL-7R\u8ef8\u304c\u30d1\u30a4\u30a8\u30eb\u677f\u3078\u306e\u65e5\u4e2d\u306eT\u7d30\u80de\u30db\u30fc\u30df\u30f3\u30b0\u3092\u8a98\u5c0e\u3057\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u304c\u30d1\u30a4\u30a8\u30eb\u677f\u306eTfh\u7d30\u80de\u5206\u5316\u3068B\u7d30\u80de\u5fdc\u7b54\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u89b3\u5bdf\u306f\u3001\u7c98\u819c\u514d\u75ab\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u65b0\u3057\u3044\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u7c98\u819c\u514d\u75ab\u7cfb\u306f\u3001\u98df\u7269\u6d88\u5316\u3084\u5171\u751f\u7d30\u83cc\u306e\u6d3b\u52d5\u306a\u3069\u306e\u6982\u65e5\u632f\u52d5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib22\">\u30d5\u30bb\u30a4\u30f3\u3068\u30d1\u30f3\u30012009\u5e74<\/a>\uff09\u3002\u3053\u308c\u306f\u6b21\u306bTLR\u306e\u6d3b\u6027\u5316\u3068\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306b\u3088\u308bT\u7d30\u80de\u306e\u84c4\u7a4d\u3068\u3068\u3082\u306b\u3001\u7c98\u819c\u514d\u75ab\u7cfb\u304c\u4fb5\u5165\u3057\u305f\u7d30\u83cc\u3092\u53d6\u308a\u9664\u304f\u306e\u3092\u52a9\u3051\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u8178\u4e0a\u76ae\u7d30\u80de\u306f\u6982\u65e5\u30ea\u30ba\u30e0\u3067\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3092\u7523\u751f\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Cima et al\u3002\u30012004<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u30d5\u30bb\u30a4\u30f3\u3068\u30d1\u30f3\u30012009\u5e74<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">Mukherji et al\u3002\u30012013<\/a>\uff09\u3001\u8178\u306e\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3082\u7c98\u819c\u514d\u75ab\u3092\u5f37\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u7c98\u819c\u514d\u75ab\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u5f79\u5272\u306f\u3001\u5c06\u6765\u306e\u7814\u7a76\u3067\u8abf\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6027\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u305f\u3081\u3001\u9ad8\u30b9\u30c8\u30ec\u30b9\u3001\u4ea4\u4ee3\u52e4\u52d9\u3001\u6162\u6027\u75b2\u52b4\u306e\u671f\u9593\u4e2d\u306e\u4e0d\u898f\u5247\u306a\u7523\u751f\u306f\u3001\u3053\u306e\u7814\u7a76\u3067\u8abf\u67fb\u3057\u305f\u514d\u75ab\u6a5f\u80fd\u306e\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4ed6\u65b9\u3001\uff27\uff32\u306b\u5bfe\u3057\u3066\u3088\u308a\u5f37\u3044\u89aa\u548c\u6027\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u5408\u6210\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u81e8\u5e8a\u6295\u4e0e\u306f\u3001\u304a\u305d\u3089\u304f\u5185\u56e0\u6027\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u30ec\u30d9\u30eb\u306e\u65e5\u5185\u5909\u5316\u3092\u6df7\u4e71\u3055\u305b\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u514d\u75ab\u7cfb\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u514d\u75ab\u5897\u5f37\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0085\">STAR\u2605\u30e1\u30bd\u30c3\u30c9<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;\u4e3b\u306a\u30ea\u30bd\u30fc\u30b9\u8868<\/h3>\n\n\n\n<table class=\"wp-block-table\"><thead><tr><th>\u8a66\u85ac\u307e\u305f\u306f\u30ea\u30bd\u30fc\u30b9<\/th><th>\u30bd\u30fc\u30b9<\/th><th>\u8b58\u5225\u5b50<\/th><\/tr><\/thead><tbody><tr><td><strong>\u6297\u4f53<\/strong><\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD3\u03b5\uff08145-2C11\uff09-FITC<\/td><td>TONBO\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9<\/td><td>Cat\uff0335-0031<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD3\u03b5\uff08145-2C11\uff09<\/td><td>\u793e\u5185<\/td><td>\u8a72\u5f53\u306a\u3057<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9TCR\u03b2\uff08H57-597\uff09-FITC<\/td><td>BioLegend<\/td><td>Cat\uff03109206; RRID\uff1aAB_313429<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9TCR\u03b2\uff08H57-597\uff09-\u30d3\u30aa\u30c1\u30f3<\/td><td>BioLegend<\/td><td>Cat\uff03109204; RRID\uff1aAB_313427<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD4\uff08RM4-5\uff09-APC-eFluor 780<\/td><td>eBioscience<\/td><td>Cat\uff0347-0042;&nbsp;RRID\uff1aAB_1272183<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD8a\uff0853-6.7\uff09-eFluor 450<\/td><td>eBioscience<\/td><td>Cat\uff0348-0081;&nbsp;RRID\uff1aAB_1272198<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD8a\uff0853-6.7\uff09-PE-Cy7<\/td><td>TONBO\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9<\/td><td>Cat\uff0360-0081<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD11a\uff08M17 \/ 4\uff09-PE<\/td><td>BioLegend<\/td><td>Cat\uff03101107;&nbsp;RRID\uff1aAB_312780<\/td><\/tr><tr><td>\u30a2\u30f3\u30c1\u30de\u30a6\u30b9CD25\uff08PC61.5\uff09-APC<\/td><td>TONBO\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9<\/td><td>Cat\uff0320-0251;<\/td><\/tr><tr><td>\u6297\u30d2\u30c8\/\u30de\u30a6\u30b9CD44\uff08IM7\uff09-PE-Cy7<\/td><td>eBioscience<\/td><td>Cat\uff0325-0441;&nbsp;RRID\uff1aAB_469622<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9NK1.1\uff08PK136\uff09-PE-Cy7<\/td><td>BioLegend<\/td><td>Cat\uff03108714;&nbsp;RRID\uff1aAB_389364<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9NK1.1PE\uff08PK136\uff09-PE<\/td><td>TONBO\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9<\/td><td>Cat\uff0350-5941<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CD69\uff08H1.2F3\uff09-PE<\/td><td>eBioscience<\/td><td>Cat\uff0312-0691;&nbsp;RRID\uff1aAB_465731<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9PD-1\uff0829F.1A12\uff09-APC<\/td><td>BioLegend<\/td><td>Cat\uff03135209;&nbsp;RRID\uff1aAB_2159183<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CXCR4\uff08L276F12\uff09-\u30d3\u30aa\u30c1\u30f3<\/td><td>BioLegend<\/td><td>Cat\uff03146516;&nbsp;RRID\uff1aAB_2056787<\/td><\/tr><tr><td>\u30e9\u30c3\u30c8IgG2b\u3001\u03ba\u3001\u30a2\u30a4\u30bd\u30bf\u30a4\u30d7\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff08RTK4530\uff09-\u30d3\u30aa\u30c1\u30f3<\/td><td>BioLegend<\/td><td>Cat\uff03400604<\/td><\/tr><tr><td>\u6297\u30de\u30a6\u30b9CXCR5\uff08L138D7\uff09-\u30d3\u30aa\u30c1\u30f3<\/td><td>BioLegend<\/td><td>Cat#145519; RRID: AB_2562865<\/td><\/tr><tr><td>Anti-mouse CCR7 (4B12)-PE<\/td><td>BioLegend<\/td><td>Cat#120105; RRID: AB_389357<\/td><\/tr><tr><td>Anti-mouse CD62L (MEL-14)-APC<\/td><td>BioLegend<\/td><td>Cat#104411; RRID: AB_313098<\/td><\/tr><tr><td>Anti-mouse CD95 (15A7)-biotin<\/td><td>eBioscience<\/td><td>Cat#13-0951-81; RRID: AB_466544<\/td><\/tr><tr><td>Anti-human\/mouse GL7 antigen (GL7)-PE<\/td><td>BioLegend<\/td><td>Cat#144607; RRID: AB_2562925<\/td><\/tr><tr><td>Anti-human\/mouse B220 (RA3-6B2)-APC-eFluor 780<\/td><td>eBioscience<\/td><td>Cat#47-0452; RRID: AB_1518810<\/td><\/tr><tr><td>Anti-human\/mouse B220 (RA3-6B2)-biotin<\/td><td>TONBO Biosciences<\/td><td>Cat#30-0452<\/td><\/tr><tr><td>Anti-mouse CD19 (6D5)-PE-Cy7<\/td><td>BioLegend<\/td><td>Cat#115520; RRID: AB_313655<\/td><\/tr><tr><td>Anti-mouse CD19 (6D5)-Alexa Fluor 488<\/td><td>BioLegend<\/td><td>Cat#115521; RRID: AB_389307<\/td><\/tr><tr><td>Anti-mouse IgG1 (RMG1-1)-APC<\/td><td>BioLegend<\/td><td>Cat#406609; RRID: AB_10679040<\/td><\/tr><tr><td>Anti-mouse IFN\u03b3 (XMG1.2)-FITC<\/td><td>eBioscience<\/td><td>Cat#11-7311; RRID: AB_465412<\/td><\/tr><tr><td>Anti-mouse IFN\u03b3 (AN-18)<\/td><td>BioLegend<\/td><td>Cat#517901; RRID: AB_10900809<\/td><\/tr><tr><td>Anti-mouse IL-2 (JES6-5H4)-APC<\/td><td>BioLegend<\/td><td>Cat#503809; RRID: AB_315303<\/td><\/tr><tr><td>Anti-mouse IL-4 (11B11)-Alexa Fluor 488<\/td><td>BioLegend<\/td><td>Cat#504111; RRID: AB_493321<\/td><\/tr><tr><td>Anti-mouse IL-4 (11B11)<\/td><td>TONBO Biosciences<\/td><td>Cat#70-7041<\/td><\/tr><tr><td>Anti-mouse IL-13 (eBio13A)-PE<\/td><td>eBioscience<\/td><td>Cat#12-7133; RRID: AB_763559<\/td><\/tr><tr><td>Anti-mouse E4BP4 (S2M-E19)-PE<\/td><td>eBioscience<\/td><td>Cat#12-5927; RRID: AB_11149135<\/td><\/tr><tr><td>Anti-mouse GATA3 (16E10A23)-APC<\/td><td>BioLegend<\/td><td>Cat#653805; RRID: AB_2562724<\/td><\/tr><tr><td>Anti-mouse CD45.2 (104)-APC<\/td><td>eBioscience<\/td><td>Cat#17-0454; RRID: AB_469400<\/td><\/tr><tr><td>Anti-mouse CD122 (TM-beta1)-biotin<\/td><td>Dr. Masayuki Miyasaka, in house<\/td><td>N\/A<\/td><\/tr><tr><td>Anti-mouse CD127 (A7R34)-biotin<\/td><td>BioLegend<\/td><td>Cat#135006; RRID: AB_2126118<\/td><\/tr><tr><td>Rat IgG2a, \u03ba, isotype control (RTK2758)-biotin<\/td><td>BioLegend<\/td><td>Cat#400504<\/td><\/tr><tr><td>Anti-mouse STAT5-pY694 (47)-PE<\/td><td>BD biosciences<\/td><td>Cat#612567<\/td><\/tr><tr><td>Anti-mouse IgG1 isotype-PE<\/td><td>BD biosciences<\/td><td>Cat#555749<\/td><\/tr><tr><td>Anti-mouse Bcl-2 set PE<\/td><td>BD biosciences<\/td><td>Cat#556537<\/td><\/tr><tr><td>Anti-mouse CD31 (MEC13.3)-PE<\/td><td>Biolegend<\/td><td>Cat#102507; RRID: AB_312914<\/td><\/tr><tr><td>Anti-mouse CD31 (MEC13.3)-FITC<\/td><td>Biolegend<\/td><td>Cat#102506; RRID: AB_312913<\/td><\/tr><tr><td>Anti-mouse CD31 (MEC13.3)-Alexa Fluor 647<\/td><td>Biolegend<\/td><td>Cat#102515; RRID: AB_2161030<\/td><\/tr><tr><td>Rabbit anti-GFP<\/td><td>Invitrogen<\/td><td>Cat#A-11122; RRID: AB_221569<\/td><\/tr><tr><td>Anti-rabbit IgG (Poly4064)-DyLight 649<\/td><td>Biolegend<\/td><td>Cat#406406; RRID: AB_1575135<\/td><\/tr><tr><td>Anti-mouse CD28 (PV-1)<\/td><td>Gift from Dr. Ryo Abe<\/td><td>N\/A<\/td><\/tr><tr><td>Streptavidin-PE<\/td><td>eBioscience<\/td><td>Cat#12-4312-87<\/td><\/tr><tr><td>Streptavidin-Brilliant Violet 421<\/td><td>BioLegend<\/td><td>Cat#405225<\/td><\/tr><tr><td>SBA clonotyping system-HRP<\/td><td>Southern Biotech<\/td><td>Cat#5300-05<\/td><\/tr><tr><td>Anti-glucocorticoid receptor mouse mAb (BuGR2)<\/td><td>Merck<\/td><td>Cat#GR32L-100UGCN<\/td><\/tr><tr><td>Whole mouse IgG<\/td><td>Jackson ImmunoResearch<\/td><td>Cat#015-000-003<\/td><\/tr><tr><td><strong>Bacterial and Virus Strains<\/strong><\/td><\/tr><tr><td><em>Listeria monocytogenes<\/em>: OVA-expressing recombinant, rLM-OVA<\/td><td>Dr. Yasunobu Yoshikai, originally from Dr. Leo Lefrancois<\/td><td>(<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib35\">Pope et&nbsp;al., 2001<\/a>)<\/td><\/tr><tr><td>AxCANCre: Cre-expressing adenovirus, AdV-Cre<\/td><td>Dr. Izumu Saito<\/td><td>(<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib24\">Kanegae et&nbsp;al., 1995<\/a>)<\/td><\/tr><tr><td><strong>Chemicals, Peptides, and Recombinant Proteins<\/strong><\/td><\/tr><tr><td>Recombinant mouse IL-7<\/td><td>BioLegend<\/td><td>Cat#577806<\/td><\/tr><tr><td>Recombinant mouse CXCL12<\/td><td>TONBO Biosciences<\/td><td>Cat#21-8141<\/td><\/tr><tr><td>Recombinant mouse IL-4<\/td><td>BioLegend<\/td><td>Cat#588204<\/td><\/tr><tr><td>Recombinant mouse IL-12<\/td><td>PeproTech<\/td><td>Cat#210-12<\/td><\/tr><tr><td>Recombinant human IL-2<\/td><td>BioLegend<\/td><td>Cat#589102<\/td><\/tr><tr><td>PMA<\/td><td>Cayman<\/td><td>Cat#10008014<\/td><\/tr><tr><td>Ionomycin<\/td><td>Cayman<\/td><td>Cat#10004974<\/td><\/tr><tr><td>Brefeldin A<\/td><td>Cayman<\/td><td>Cat#11861<\/td><\/tr><tr><td>5-(and \u22126)-Carboxyfluorescein diacetate succinimidyl ester (CFSE)<\/td><td>Dojindo<\/td><td>Cat#341-07401<\/td><\/tr><tr><td>5-(6)-(((4-Chloromethyl)Benzoyl)Amino)Tetramethylrhodamine (CMTMR)<\/td><td>Setareh Biotech<\/td><td>Cat#7138<\/td><\/tr><tr><td>CellTracker Deep Red<\/td><td>Thermo Fisher Scientific<\/td><td>Cat#C34565<\/td><\/tr><tr><td>Dexamethasone<\/td><td>Sigma-Aldrich<\/td><td>Cat#D4092<\/td><\/tr><tr><td>Dexamethasone 21-phosphate disodium salt<\/td><td>Sigma-Aldrich<\/td><td>Cat#D1159<\/td><\/tr><tr><td>Albumin from chicken egg white (OVA)<\/td><td>Sigma-Aldrich<\/td><td>Cat#A5503<\/td><\/tr><tr><td>Bovine serum albumin (BSA)<\/td><td>Nacalai Tesque<\/td><td>Cat#08587-26<\/td><\/tr><tr><td>NP-OVAL<\/td><td>LGC Biosearch Technologies<\/td><td>Cat#N-5051-10<\/td><\/tr><tr><td>NP-BSA<\/td><td>LGC Biosearch Technologies<\/td><td>Cat#N-5050H-10<\/td><\/tr><tr><td>Imject Alum Adjuvant<\/td><td>Thermo Fisher Scientific<\/td><td>Cat#77161<\/td><\/tr><tr><td>DNase I<\/td><td>Worthington Biochemical<\/td><td>Cat#DT<\/td><\/tr><tr><td>Collagenase D<\/td><td>Sigma-Aldrich<\/td><td>Cat#11088882001<\/td><\/tr><tr><td>Percoll<\/td><td>GE Healthcare<\/td><td>Cat#17-0891-01<\/td><\/tr><tr><td>ABTS<\/td><td>Sigma-Aldrich<\/td><td>Cat#10102946001<\/td><\/tr><tr><td>RPMI 1640 Medium<\/td><td>Nacalai Tesque<\/td><td>Cat#30246-85<\/td><\/tr><tr><td>FBS<\/td><td>ICN Biomedicals<\/td><td>Cat#29-167-54<\/td><\/tr><tr><td>Sepasol RNA I SuperG<\/td><td>Nacalai Tesque<\/td><td>Cat#09379-97<\/td><\/tr><tr><td>Recombinant DNase I (RNase-free)<\/td><td>Takara Bio<\/td><td>Cat#2270A<\/td><\/tr><tr><td>RNase Inhibitor<\/td><td>Takara Bio<\/td><td>Cat#2313A<\/td><\/tr><tr><td>ReverTra Ace<\/td><td>TOYOBO<\/td><td>Cat#TRT-101<\/td><\/tr><tr><td>Random Primers<\/td><td>Invitrogen<\/td><td>Cat#48190-011<\/td><\/tr><tr><td>ROX Reference Dye<\/td><td>Invitrogen<\/td><td>Cat#12223-012<\/td><\/tr><tr><td><strong>Critical Commercial Assays<\/strong><\/td><\/tr><tr><td>Foxp3 Staining Buffer Set<\/td><td>eBioscience<\/td><td>Cat#00-5523-00<\/td><\/tr><tr><td>IC Fixation Buffer<\/td><td>eBioscience<\/td><td>Cat#00-8222-49<\/td><\/tr><tr><td>EasySep Mouse Naive CD4+ T Isolation Kit<\/td><td>STEMCELL Technologies<\/td><td>Cat#ST19765<\/td><\/tr><tr><td>EasySep Mouse Naive CD8+ T Isolation Kit<\/td><td>STEMCELL Technologies<\/td><td>Cat#ST19858<\/td><\/tr><tr><td>Pan T Cell Isolation Kit II, mouse<\/td><td>Miltenyi Biotech<\/td><td>Cat#130-095-130<\/td><\/tr><tr><td>CaspGLOW Fluorescein Active Caspase-3 Staining kit<\/td><td>Thermo Fisher Scientific<\/td><td>Cat#88-7004-42<\/td><\/tr><tr><td>QuikChange Site-Directed Mutagenesis Kit<\/td><td>Agilent Technologies<\/td><td>Cat#200519<\/td><\/tr><tr><td>Mouse IL-4 ELISA Ready-SET-Go Kit<\/td><td>eBioscience<\/td><td>Cat#88-7044-22<\/td><\/tr><tr><td>Mouse IL-13 ELISA Ready-SET-Go Kit<\/td><td>eBioscience<\/td><td>Cat#88-7137-22<\/td><\/tr><tr><td>Transwell 24 well, 6.5&nbsp;mm diameter, 5&nbsp;\u03bcm pore<\/td><td>Corning<\/td><td>Cat#3421<\/td><\/tr><tr><td>T-select MHC I Tetramer (H-2Kb OVA Tetramer APC)<\/td><td>Medical &amp; Biological Laboratories<\/td><td>Cat#TS-5001-2C<\/td><\/tr><tr><td>Protein G Sepharose 4 Fast Flow<\/td><td>GE Healthcare<\/td><td>Cat#17061802<\/td><\/tr><tr><td>QuantiTect SYBR Green PCR Kit<\/td><td>QIAGEN<\/td><td>Cat#204145<\/td><\/tr><tr><td><strong>Experimental Models: Organisms\/Strains<\/strong><\/td><\/tr><tr><td>Mouse: C57BL\/6<\/td><td>Japan SLC<br><br>CLEA Japan<\/td><td>C57BL\/6<\/td><\/tr><tr><td>Mouse: C57BL\/6-CD45.1: B6.SJL-<em>Ptprc<\/em><sup>a<\/sup>&nbsp;<em>Pepc<\/em><sup>b<\/sup>\/BoyJ<\/td><td>Dr. Irving L. Weissman<\/td><td>JAX:002014<\/td><\/tr><tr><td>Mouse:&nbsp;<em>CD4<\/em>-cre: B6.Cg-Tg(Cd4-cre)1Cwi<\/td><td>Dr. Christopher B. Wilson<\/td><td>JAX:022071<\/td><\/tr><tr><td>Mouse:&nbsp;<em>Nr3c1<\/em><sup>fl\/fl<\/sup>: B6.129-<em>Nr3c1<\/em><sup>tm2Gsc<\/sup>,<\/td><td>Dr. G\u00fcnther Sch\u00fctz<\/td><td>EM:02124<\/td><\/tr><tr><td>Mouse:&nbsp;<em>Il7r<\/em><sup>fl\/fl<\/sup>: B6.129-<em>Il7r<\/em><sup>tm2Iku<\/sup><\/td><td>Lab of Koichi Ikuta<\/td><td>N\/A<\/td><\/tr><tr><td>Mouse:&nbsp;<em>Cxcr4<\/em><sup>fl\/fl<\/sup>: B6.129-<em>Cxcr4<\/em><sup>tm2Tng<\/sup><\/td><td>Dr. Takashi Nagasawa<\/td><td>RBRC:04198<\/td><\/tr><tr><td>Mouse:&nbsp;<em>Cxcl12<\/em>-GFP: B6.129-<em>Cxcl12<\/em><sup>tm2Tng<\/sup><\/td><td>Dr. Takashi Nagasawa<\/td><td>RBRC:04200<\/td><\/tr><tr><td>Mouse:&nbsp;<em>Il7<\/em>\u2013GFP: B6.129-<em>Il7<\/em><sup>tm1.1Iku<\/sup><\/td><td>Lab of Koichi Ikuta<\/td><td>N\/A<\/td><\/tr><tr><td>Mouse: GRE1m:&nbsp;<em>Il7r<\/em><sup>CNS1.GRE1m\/1 m<\/sup><\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Mouse: GRE2m:&nbsp;<em>Il7r<\/em><sup>CNS1.GRE2m\/2 m<\/sup><\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Mouse: GRE12m:&nbsp;<em>Il7r<\/em><sup>CNS1.GRE12m\/12 m<\/sup><\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td><strong>Oligonucleotides<\/strong><\/td><\/tr><tr><td>Gapdh primer:<br><br>F: CCTCGTCCCGTAGACAAAATG;<br><br>R: TCTCCACTTTGCCACTGCAA<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>IL-7R primer:<br><br>F: GGATGGAGACCTAGAAGATG;<br><br>R: GAGTTAGGCATTTCACTCGT<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>CXCR4 primer:<br><br>F: TGTTGCCATGGAACCGATCA;<br><br>R: TGGTGGGCAGGAAGATCCTA<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Bcl2 primer:<br><br>F: TCGCTACCGTCGTGACTTC;<br><br>R: AAACAGAGGTCGCATGCTG<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>BclxL primer:<br><br>F: GGAGAGCGTTCAGTGATC;<br><br>R: CAATGGTGGCTGAAGAGA<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>IL-4 primer:<br><br>F: AGGAGCCATATCCACGGATG;<br><br>R: ACAGACGAGCTCACTCTCTG<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>IL-13 primer:<br><br>F: CAGCTCCCTGGTTCTCTCAC;<br><br>R: ACACTCCATACCATGCTGCC<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Primers for 5\u2032 homologous fragment of the targeting vector, see Experimental Procedures and&nbsp;<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">Figure&nbsp;S2<\/a>:<br><br>F: TCTTATGGAGGCTTTGGAGG<br><br>R: GAGTCTTTGGGCACCTGAGA<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Primers for 3\u2032 homologous fragment of the targeting vector, see Experimental Procedures and&nbsp;<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">Figure&nbsp;S2<\/a>:<br><br>F: CTTTTTTCATCTTCCTTTCAAAC<br><br>R: ATGTCACTTGAGTGGCAGAC<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Primers for probe A, see Experimental Procedures and&nbsp;<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">Figure&nbsp;S2<\/a>:<br><br>F: TACCAACTTTGAAGCTGCTG<br><br>R: CCTCCAAAGCCTCCATAAGA<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td>Primers for probe B, see Experimental Procedures and&nbsp;<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">Figure&nbsp;S2<\/a>:<br><br>F: TGCAAAGGAAGGAGTGTCTG<br><br>R: GCACATACATATGCTTGTGG<\/td><td>This paper<\/td><td>N\/A<\/td><\/tr><tr><td><strong>Software and Algorithms<\/strong><\/td><\/tr><tr><td>FlowJo v10.2<\/td><td>Tree Star<\/td><td>RRID:SCR_008520<\/td><\/tr><tr><td>GraphPad Prism 7.0<\/td><td>GraphPad Software<\/td><td>RRID:SCR_002798<\/td><\/tr><tr><td>\u30e9\u30a4\u30abLASAF\u753b\u50cf\u53d6\u5f97\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2<\/td><td>\u30e9\u30a4\u30ab\u30de\u30a4\u30af\u30ed\u30b7\u30b9\u30c6\u30e0\u30ba<\/td><td>RRID\uff1aSCR_013673<\/td><\/tr><\/tbody><\/table>\n\n\n\n<ul class=\"wp-block-list\"><li><a target=\"_blank\" href=\"https:\/\/www.cell.com\/action\/showFullTableHTML?isHtml=true&amp;tableId=undtbl1&amp;pii=S1074-7613%2818%2930004-9\" rel=\"noreferrer noopener\">\u65b0\u3057\u3044\u30bf\u30d6\u3067\u30c6\u30fc\u30d6\u30eb\u3092\u958b\u304f<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;\u8a66\u85ac\u3068\u30ea\u30bd\u30fc\u30b9\u5171\u6709\u306e\u9023\u7d61\u5148<\/h3>\n\n\n\n<p>\u30ea\u30bd\u30fc\u30b9\u3068\u8a66\u85ac\u306e\u8a73\u7d30\u304a\u3088\u3073\u8981\u6c42\u306f\u3001\u30ea\u30fc\u30c9\u30b3\u30f3\u30bf\u30af\u30c8\u306e\u751f\u7530\u6d69\u4e00\u535a\u58eb\uff08<a href=\"mailto:ikuta.koichi.6c@kyoto-u.ac.jp\" target=\"_blank\" rel=\"noreferrer noopener\">ikuta.koichi.6c@kyoto-u.ac.jp<\/a>\uff09\u306b<a href=\"mailto:ikuta.koichi.6c@kyoto-u.ac.jp\" target=\"_blank\" rel=\"noreferrer noopener\">\u9001\u4fe1<\/a>\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u4e3b\u984c\u306e\u8a73\u7d30<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30de\u30a6\u30b9<\/h4>\n\n\n\n<p>B6.SJL-&nbsp;<em>Ptprc&nbsp;<\/em><sup>a&nbsp;<\/sup><em>Pepc&nbsp;<\/em><sup>b<\/sup>&nbsp;\/ BoyJ\uff08B6.CD45.1\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\uff09\u3001B6.Cg-Tg\uff08Cd4-cre\uff091Cwi\uff08<em>Cd4<\/em>&nbsp;&#8211;&nbsp;cre\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib28\">Lee et al\u3002\u30012001<\/a>\uff09\u3001B6.129-&nbsp;<em>Nr3c1&nbsp;<\/em><sup>tm2Gsc<\/sup>\uff08<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl<\/sup>\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib44\">Tronche et al\u3002\u30011999<\/a>\uff09\u3001B6.129-&nbsp;<em>Cxcr4&nbsp;<\/em><sup>tm2Tng<\/sup>\uff08<em>Cxcr4&nbsp;<\/em><sup>fl \/ fl<\/sup>\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib43\">\u30c8\u30b3\u30e8\u30c0\u4ed6\u30012004\u5e74<\/a>\uff09\u3001B6.129-&nbsp;<em>Il7r&nbsp;<\/em><sup>tm2Iku<\/sup>\uff08<em>Il7r&nbsp;<\/em><sup>fl \/ fl<\/sup>\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib42\">\u8c37\u4e00\u307b\u304b\u30012013\u5e74<\/a>\uff09\u3001B6.129-&nbsp;<em>Cxcl12&nbsp;<\/em><sup>tm2Tng<\/sup>\uff08<em>Cxcl12 -GFP<\/em>\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib2\">Ara et al\u3002\u30012003<\/a>\uff09\u3001\u304a\u3088\u3073B6.129-&nbsp;<em>Il7&nbsp;<\/em><sup>tm1.1Iku<\/sup>\uff08<em>Il7 \u2013GFP<\/em>\uff09\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib18\">\u539f\u307b\u304b\u30012012\u5e74<\/a>\uff09\u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u30de\u30a6\u30b9\u306f\u3001\u4eac\u90fd\u5927\u5b66\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u751f\u547d\u533b\u5b66\u7814\u7a76\u6240\u306e\u611f\u67d3\u75c7\u5b9f\u9a13\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3067\u7279\u5b9a\u75c5\u539f\u4f53\u9664\u53bb\u6761\u4ef6\u4e0b\u3067\u98fc\u80b2\u3055\u308c\u307e\u3057\u305f\u3002\u5b9f\u9a13\u306f6\u301c12\u9031\u9f62\u306e\u30aa\u30b9\u3068\u30e1\u30b9\u306e\u30de\u30a6\u30b9\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u611f\u67d3\u307e\u305f\u306f\u514d\u75ab\u30a2\u30c3\u30bb\u30a4\u3067\u306f\u30018\u301c14\u9031\u9f62\u306e\u30aa\u30b9\u3068\u30e1\u30b9\u306e\u30de\u30a6\u30b9\u3067\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig2\">\u56f3<\/a>2D\u3001<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#fig3\">3<\/a>&nbsp;I\u30013J\u3001<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">S4<\/a>\u306e\u5b9f\u9a13\u3092\u9664\u3044\u3066\u3001\u540c\u6027\u306e\u540c\u6027\u306e\u5bfe\u7167\u30de\u30a6\u30b9\u3068\u5909\u7570\u30de\u30a6\u30b9\u306e\u5404\u30da\u30a2\u3092\u540c\u6642\u306b\u5206\u6790\u3057\u3001\u8907\u6570\u306e\u540c\u6027\u5150\u306b\u7531\u6765\u3059\u308b\u6df7\u5408\u6027\u306e\u8907\u6570\u306e\u30da\u30a2\u304b\u3089\u30c7\u30fc\u30bf\u3092\u30d7\u30fc\u30eb\u3057\u307e\u3057\u305f\u3002<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\"><\/a>C\u3001\u304a\u3088\u3073S4D\u3002\u7570\u306a\u308b\u540c\u8179\u4ed4\u306e\u30de\u30a6\u30b9\u3092\u540c\u6642\u306b\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u52d5\u7269\u306e\u82e6\u75db\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u306b\u3001\u3059\u3079\u3066\u306e\u624b\u9806\u306f\u30bb\u30dc\u30d5\u30eb\u30e9\u30f3\u9ebb\u9154\u4e0b\u3067\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u306f\u3001\u6e7f\u5ea6\u3001\u6e29\u5ea6\u3001\u304a\u3088\u3073\u5149\u306e\u5236\u5fa1\u3055\u308c\u305f\u6761\u4ef6\u4e0b\uff0812\u6642\u9593\u306e\u660e\/ 12\u6642\u9593\u306e\u6697\u30b5\u30a4\u30af\u30eb\uff09\u3067\u30b0\u30eb\u30fc\u30d7\u306b\u53ce\u5bb9\u3055\u308c\u305f\u3002\u98df\u7269\u3068\u6c34\u306f<em>\u81ea\u7531\u306b\u6442\u53d6<\/em>\u3067\u304d\u305f\u3002\u3059\u3079\u3066\u306e\u30de\u30a6\u30b9\u30d7\u30ed\u30c8\u30b3\u30eb\u306f\u3001\u4eac\u90fd\u5927\u5b66\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u751f\u547d\u533b\u5b66\u7814\u7a76\u6240\u306e\u52d5\u7269\u5b9f\u9a13\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;GRE\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u30de\u30a6\u30b9\u306e\u751f\u6210<\/h4>\n\n\n\n<p>\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u30d9\u30af\u30bf\u30fc\u3092\u69cb\u7bc9\u3059\u308b\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306eDNA\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u30d9\u30af\u30bf\u30fcpBluescript KS\uff08+\uff09\u306b\u30a2\u30bb\u30f3\u30d6\u30eb\u3057\u307e\u3057\u305f\uff1a\u30b8\u30d5\u30c6\u30ea\u30a2\u6bd2\u7d20A\u30ab\u30bb\u30c3\u30c8\u3001IL-7R\u03b1\u907a\u4f1d\u5b50\u5ea7\u306e5&#8217;CNS1\u30a8\u30ec\u30e1\u30f3\u30c8\u306e1,822 bp\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3001\u30cd\u30aa\u30de\u30a4\u30b7\u30f3\u8010\u6027\u907a\u4f1d\u5b50\u30ab\u30bb\u30c3\u30c8\u306b\u96a3\u63a5<em>lox<\/em>&nbsp;P\u914d\u5217\u3001\u53ca\u3073\u5909\u7570CNS1\u7d20\u5b50\u304a\u3088\u30733 &#8216;CNS1\u9818\u57df\u3092\u542b\u30808521-bp\u65ad\u7247\u3002CNS1\u30a8\u30ec\u30e1\u30f3\u30c8\u306e<em>invitro<\/em>\u7a81\u7136\u5909\u7570\u8a98\u767a\u306f\u3001QuikChange\u90e8\u4f4d\u7279\u7570\u7684\u7a81\u7136\u5909\u7570\u8a98\u767a\u30ad\u30c3\u30c8\uff08Agilent Technologies\uff09\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002GRE1\u304a\u3088\u3073GRE2\u306e\u5909\u7570\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3042\u308a\u3001\u5909\u7570\u3057\u305f\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u306f\u4e0b\u7dda\u304c\u5f15\u304b\u308c\u3066\u3044\u307e\u3059\u3002GRE1\u91ce\u751f\u578b\u30015&#8242;-CTTTGTTCTTTTACATCTTCA-3 &#8216;\u3002GRE1m\u30015&#8217;-CTT&nbsp;CAC&nbsp;T&nbsp;GC&nbsp;TTT&nbsp;GAG&nbsp;T&nbsp;GCTCA-3 &#8216;;&nbsp;GRE2\u91ce\u751f\u578b\u30015&#8217;-TAGCACATGCTGTACC-3 &#8216;;&nbsp;\u304a\u3088\u3073GRE2m\u30015&#8217;-TAGC&nbsp;GAG&nbsp;TGCTGTACC-3 &#8216;\u3002\u7dda\u5f62\u5316\u3055\u308c\u305f\u30d9\u30af\u30bf\u30fc\u306f\u3001\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066KY1.1 ES\u7d30\u80de\uff08C57BL \/ 6\u00d7129S6 \/ SvEvTac F1\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\uff09\u306b\u5c0e\u5165\u3055\u308c\u3001\u76f8\u540c\u7d44\u63db\u3048\u4f53\u306fPCR\u306b\u3088\u3063\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u307e\u3057\u305f\u3002\u6a19\u7684ES\u30af\u30ed\u30fc\u30f3\u306f\u30015 &#8216;\u304a\u3088\u30733&#8217;\u30d7\u30ed\u30fc\u30d6\u3092\u7528\u3044\u305f\u30b5\u30b6\u30f3\u30d6\u30ed\u30c3\u30c8\u5206\u6790\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1\">\u56f3S2<\/a>&nbsp;A\u2013S2C\uff09\u3002\u30cd\u30aa\u30de\u30a4\u30b7\u30f3\u8010\u6027\u907a\u4f1d\u5b50\u30ab\u30bb\u30c3\u30c8\u306f\u3001Cre\u30ea\u30b3\u30f3\u30d3\u30ca\u30fc\u30bc\u3092\u767a\u73fe\u3059\u308b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9AdV-Cre\uff08\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u306e\u9f4b\u85e4\u3044\u305a\u3080\u535a\u58eb\u304b\u3089\u306e\u89aa\u5207\u306a\u8d08\u308a\u7269\uff09\u3092<em>invitro<\/em>\u3067\u6a19\u7684ES\u30af\u30ed\u30fc\u30f3<em>\u306b<\/em>\u611f\u67d3\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u7d44\u63db\u3048\u5bfe\u7acb\u907a\u4f1d\u5b50\u304b\u3089\u9664\u53bb\u3055\u308c\u305f\u3002\u5f97\u3089\u308c\u305fES\u30af\u30ed\u30fc\u30f3\u306b\u306f<em>lox\u306e<\/em>\u30b3\u30d4\u30fc\u304c1\u3064\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f<em><\/em>\u5909\u7570\u3057\u305fCNS1\u30a8\u30ec\u30e1\u30f3\u30c8\u306e5 &#8216;\u5074\u306eP\u90e8\u4f4d\u3002ES\u30af\u30ed\u30fc\u30f3\u3092ICR8\u7d30\u80de\u80da\u306b\u6ce8\u5165\u3057\u307e\u3057\u305f\u3002\u30ad\u30e1\u30e9\u30de\u30a6\u30b9\u3092C57BL \/ 6\u30de\u30a6\u30b9\u3068\u4ea4\u914d\u3057\u3001GRE\u5909\u7570\u30de\u30a6\u30b9\u30929\u4e16\u4ee3\u306b\u308f\u305f\u3063\u3066C57BL \/ 6\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u306b\u623b\u3057\u4ea4\u914d\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u7d30\u83cc\u611f\u67d3<\/h4>\n\n\n\n<p>OVA\uff08rLM-OVA\uff09\u3092\u767a\u73fe\u3059\u308b\u7d44\u63db\u3048<em>\u30ea\u30b9\u30c6\u30ea\u30a2\u83cc<\/em>\u306f\u4ee5\u524d\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u963f\u90e8\u307b\u304b\u30012015\u5e74<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u6559\u7687\u3089\u30012001\u5e74<\/a>\u3001&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u77e2\u5cf6\u307b\u304b\u30012005\u5e74<\/a>\uff09\u3002\u30de\u30a6\u30b9\u306f\u30012.5\u00d710\u3092\u9759\u8108\u5185\u6ce8\u5c04\u3057\u305f<sup>4<\/sup>&nbsp;ZT4\u53c8\u306fZT16\u3067CFU RLM-OVA\u30027\u65e5\uff08168\u6642\u9593\uff09\u5f8c\u3001\u813e\u81d3\u7d30\u80de\u3092\u6297\u4f53\u3067\u67d3\u8272\u3057\u305f\u3002\u7d30\u80de\u3092PBS\u4e2d\u306e0.1\uff05\u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u30674\u2103\u306720\u5206\u9593\u56fa\u5b9a\u3057\u305f\u5f8c\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;\u30e1\u30bd\u30c3\u30c9\u306e\u8a73\u7d30<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u7d30\u80de\u306e\u6e96\u5099<\/h4>\n\n\n\n<p>\u704c\u6d41\u5f8c\u3001\u80ba\u3092\u306f\u3055\u307f\u3067\u7d30\u304b\u304f\u5207\u308a\u523b\u307f\u300110\uff05FBS\u30011 mg \/ ml\u30b3\u30e9\u30b2\u30ca\u30fc\u30bcD\u3001\u304a\u3088\u307350\u03bcg\/ mlDNaseI\u3092\u542b\u3080RPMI-1640\u57f9\u5730\u306737\u2103\u30671\u6642\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u6d88\u5316\u3057\u305f\u80ba\u65ad\u7247\u309240\u306b\u901a\u3057\u307e\u3057\u305f\u3002 -\u03bcm\u30b9\u30c8\u30ec\u30fc\u30ca\u30fc\u300230\uff05\u30d1\u30fc\u30b3\u30fc\u30eb\u306b\u3088\u308b\u9060\u5fc3\u5206\u96e2\u306b\u3088\u308a\u767d\u8840\u7403\u3092\u5206\u96e2\u3057\u305f\u3002\u8d64\u8840\u7403\u3092\u6eb6\u89e3\u3057\u305f\u5f8c\u3001\u7d30\u80de\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u5206\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u6297\u4f53\u3068\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc<\/h4>\n\n\n\n<p>\u7d30\u80de\u306f\u793a\u3055\u308c\u305f\u5668\u5b98\u304b\u3089\u8abf\u88fd\u3055\u308c\u30010.05\uff05NaN&nbsp;<sub>3<\/sub>\u304a\u3088\u30730.1\uff05\u30a6\u30b7\u8840\u6e05\u30a2\u30eb\u30d6\u30df\u30f3\uff08BSA\uff09\u3092\u542b\u3080PBS\u4e2d\u30674\u2103\u306720\u5206\u9593\u6297\u4f53\u3067\u67d3\u8272\u3055\u308c\u307e\u3057\u305f\u3002\u6b21\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u86cd\u5149\u8272\u7d20\u307e\u305f\u306f\u30d3\u30aa\u30c1\u30f3\u7d50\u5408\u6297\u4f53\u306f\u3001BD Bioscience\u3001eBioscience\u3001BioLegend\u3001Invitrogen\u3001\u307e\u305f\u306fTONBO Biosciences\u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\uff1aCD3\u03b5\uff08145-2C11\uff09\u3001TCR\u03b2\uff08H57-597\uff09\u3001CD4\uff08RM4.5\uff09\u3001CD8\u03b1 \uff0853-6.7\uff09\u3001CD11a\uff08M17 \/ 4\uff09\u3001CD25\uff087D4\uff09\u3001CD44\uff08IM7\uff09\u3001NK1.1\uff08PK136\uff09\u3001CD69\uff08H1.2F3\uff09\u3001PD-1\uff0829F.1A12\uff09\u3001CXCR4\uff08L276F12\uff09 \u3001CXCR5\uff08L138D7\uff09\u3001CCR7\uff084B12\uff09\u3001CD62L\uff08MEL-14\uff09\u3001CD95\uff08Jo2\uff09\u3001GL7\u6297\u539f\uff08GL7\uff09CD45R \/ B220\uff08RA3-6B2\uff09\u3001CD19\uff086D5\uff09\u3001IgG1\uff08RMG1-1\uff09\u3001IFN -\u03b3\uff08XMG1.2\uff09\u3001IL-2\uff08JES6-5H4\uff09\u3001IL-4\uff0811B11\uff09\u3001IL-13\uff08eBio 13A\uff09\u3001E4BP4\uff08S2M-E19\uff09\u3001GATA3\uff0816E10A23\uff09\u3001CD45.2\uff08104\uff09 \u3001CD122\uff08TM-beta1\uff09\u3001CD127\uff08A7R34\uff09\u3001\u30ea\u30f3\u9178\u5316STAT5\uff0847\uff09\u3001\u304a\u3088\u3073Bcl-2\uff08A19-3\uff09\u3002H-2K<sup>b<\/sup>&nbsp;OVA G4\u30c6\u30c8\u30e9\u30de\u30fc-SIIGFEKL-PE\u306f\u3001Medical and BiologicalLaboratories\u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002\u30d3\u30aa\u30c1\u30f3\u5316\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306f\u3001PE\u307e\u305f\u306fBrilliant Violet 421\u7d50\u5408\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\uff08eBioscience\uff09\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002FlowJo\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u3066\u3001FACSCanto II\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u30fc\uff08BDBiosciences\uff09\u3067\u751f\u7d30\u80de\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u56f3\u3067\u306f\u3001\u8c61\u9650\u3001\u30b2\u30fc\u30c8\u9818\u57df\u3001\u304a\u3088\u3073\u9593\u9694\u30b2\u30fc\u30c8\u306e\u5024\u306f\u3001\u5404\u6bcd\u96c6\u56e3\u306e\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002Bcl-2\u3001GATA3\u3001\u304a\u3088\u3073E4BP4\u306e\u7d30\u80de\u5185\u67d3\u8272\u3067\u306f\u3001Foxp3\u67d3\u8272\u30d0\u30c3\u30d5\u30a1\u30fc\u30bb\u30c3\u30c8\uff08eBioscience\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001T\u7d30\u80de\u306e\u8868\u9762\u6297\u539f\u3092\u67d3\u8272\u3057\u3001\u56fa\u5b9a\u3001\u900f\u904e\u51e6\u7406\u3001\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u6297\u4f53\u3067\u67d3\u8272\u3057\u307e\u3057\u305f\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306e\u7d30\u80de\u5185\u67d3\u8272\u3067\u306f\u3001\u57f9\u990aCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092\u56fa\u5b9a\u3057\u3001\u900f\u904e\u51e6\u7406\u3057\u3001IC Fixation Buffer\uff08eBioscience\uff09\u3092\u4f7f\u7528\u3057\u3066\u95a2\u9023\u3059\u308b\u6297\u4f53\u3067\u67d3\u8272\u3057\u307e\u3057\u305f\u3002\u30ea\u30f3\u9178\u5316STAT5\u306e\u7d30\u80de\u5185\u67d3\u8272\u3067\u306f\u3001\u7d30\u80de\u3092\u56fa\u5b9a\u3057\u3001\u6c37\u51b7\u30e1\u30bf\u30ce\u30fc\u30eb\u3067\u900f\u904e\u51e6\u7406\u3057\u3001Foxp3\u67d3\u8272\u30d0\u30c3\u30d5\u30a1\u30fc\u30bb\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u6297\u30ea\u30f3\u9178\u5316STAT5\u6297\u4f53\u3067\u67d3\u8272\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u7d30\u80de\u306e\u5206\u96e2<\/h4>\n\n\n\n<p>\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>\u304a\u3088\u3073CD8T&nbsp;<sup>+<\/sup>\u7d30\u80de\u306f\u3001EasySep\u30ca\u30a4\u30fc\u30d6CD4\u304a\u3088\u3073CD8 T\u7d30\u80de\u6fc3\u7e2e\u30ad\u30c3\u30c8\uff08STEMCELL Technologies\uff09\u3092\u4f7f\u7528\u3057\u3066\u30ea\u30f3\u30d1\u7bc0\u304b\u3089\u7cbe\u88fd\u3057\u307e\u3057\u305f\u3002qPCR\u5206\u6790\u306e\u5834\u5408\u3001CD4&nbsp;<sup>+<\/sup>&nbsp;T\uff08CD3&nbsp;<sup>+<\/sup>&nbsp;CD4&nbsp;<sup>+<\/sup>&nbsp;CD25&nbsp;<sup>\u2013<\/sup>&nbsp;NK1.1&nbsp;<sup>\u2013<\/sup>\uff09\u3001CD8&nbsp;<sup>+<\/sup>&nbsp;T\uff08CD3&nbsp;<sup>+<\/sup>&nbsp;CD8&nbsp;<sup>+<\/sup>\uff09\u3001Treg\uff08CD3&nbsp;<sup>+<\/sup>&nbsp;CD4&nbsp;<sup>+<\/sup>&nbsp;CD25&nbsp;<sup>+<\/sup>\uff09\u3001\u304a\u3088\u3073Th2\u30e1\u30e2\u30ea\u30fc\uff08CD4&nbsp;<sup>+<\/sup>&nbsp;CD45.2&nbsp;<sup>+<\/sup>\uff09FACSAria II\u30bb\u30eb\u30bd\u30fc\u30bf\u30fc\uff08BDBiosciences\uff09\u3092\u7528\u3044\u3066\u80f8\u817a\u304a\u3088\u3073\u813e\u81d3\u304b\u3089\u7d30\u80de\u3092\u9078\u5225\u3057\u305f\u3002\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u3067\u306f\u3001Pan T Cell Isolation Kit\uff08Miltenyi Biotech\uff09\u3092\u4f7f\u7528\u3057\u3066T\u7d30\u80de\u3092\u7cbe\u88fd\u3057\u307e\u3057\u305f\u3002\u672b\u68a2\u8840\u4e2d\u306e\u767d\u8840\u7403\u5bc6\u5ea6\u3092Celltac\u03b1MEK6450\u5168\u81ea\u52d5\u8840\u7403\u30ab\u30a6\u30f3\u30bf\u30fc\uff08\u65e5\u672c\u5149\u96fb\u5de5\u696d\uff09\u3067\u6e2c\u5b9a\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u7d30\u80de\u57f9\u990a<\/h4>\n\n\n\n<p>\u7cbe\u88fd\u3055\u308c\u305fT\u7d30\u80de\u306f\u300110\uff05\u30a6\u30b7\u80ce\u5150\u8840\u6e05\uff08FBS\uff09\u300150\u03bcM2-\u30e1\u30eb\u30ab\u30d7\u30c8\u30a8\u30bf\u30ce\u30fc\u30eb\u3001\u304a\u3088\u307310 mM HEPES\uff08pH 7.4\uff09\u3092\u542b\u3080RPMI1640\u57f9\u5730\u3067\u57f9\u990a\u3055\u308c\u307e\u3057\u305f\u3002IL-7R\u03b1\u306e\u767a\u73fe\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u7d30\u80de\u309210&nbsp;<sup>-8<\/sup>&nbsp;M\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\uff08Sigma\uff09\u306712\u6642\u9593\u57f9\u990a\u3057\u307e\u3057\u305f\u3002CFSE\u5e0c\u91c8\u30a2\u30c3\u30bb\u30a4\u3067\u306f\u3001\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>\u304a\u3088\u3073CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092PBS\u4e2d\u306e2\u03bcMCFSE\uff08Dojindo Laboratories\uff09\u306737\u00b0C\u306710\u5206\u9593\u6a19\u8b58\u3057\u307e\u3057\u305f\u3002\u7d30\u80de\u306f\u30014\u03bcg\/ ml\u306e\u30d7\u30ec\u30fc\u30c8\u7d50\u5408\u6297CD3\u6297\u4f53\u30014\u03bcg\/ ml\u306e\u53ef\u6eb6\u6027\u6297CD28\u6297\u4f53\uff08PV-1\u3001\u6771\u4eac\u7406\u79d1\u5927\u5b66\u306e\u963f\u90e8\u535a\u58eb\u304b\u3089\u306e\u89aa\u5207\u306a\u8d08\u308a\u7269\uff09\u3001\u304a\u3088\u307320ng \/\u3067\u57f9\u990a\u3055\u308c\u307e\u3057\u305f\u3002 ml\u30d2\u30c8IL-2\uff08BioLegend\uff09\u300296\u6642\u9593\u5f8c\u3001\u7d30\u80de\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u306e\u305f\u3081<em>\u306ein vitro<\/em>\u751f\u5b58\u30a2\u30c3\u30bb\u30a4\u3001\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>\u53ca\u3073CD8&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u30925ng \/ ml IL-7\uff08BioLegend\uff09\u3067\u57f9\u990a\u3057\u3001\u30e8\u30a6\u5316\u30d7\u30ed\u30d4\u30b8\u30a6\u30e0\u9670\u6027\uff08\u3059\u306a\u308f\u3061\u751f\uff09\u7d30\u80de\u306e\u5272\u5408\u3092\u3001\u793a\u3055\u308c\u305f\u6642\u70b9\u3067\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR<\/h4>\n\n\n\n<p>\u5168RNA\u3092\u5358\u96e2\u3057\u3001\u30e9\u30f3\u30c0\u30e0\u30d7\u30e9\u30a4\u30de\u30fc\u3092\u4f7f\u7528\u3057\u3066\u9006\u8ee2\u5199\u3057\u307e\u3057\u305f\u3002cDNA\u306f\u3001ABI7500\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u30b7\u30b9\u30c6\u30e0\uff08Applied Biosystems\uff09\u3067SYBR Green PCR Master Mix\uff08QIAGEN\uff09\u3092\u4f7f\u7528\u3057\u305f\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0RT-PCR\u306b\u3088\u3063\u3066\u5206\u6790\u3055\u308c\u307e\u3057\u305f\u3002PCR\u306e\u7d50\u679c\u306f\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306e\u30ea\u30f3\u30d1\u7bc0\u7d30\u80de\u304b\u3089\u306ecDNA\u306e<em>GapdhmRNA<\/em>\u306e\u5bfe\u5fdc\u3059\u308b\u30ec\u30d9\u30eb\u306b\u5bfe\u3057\u3066\u6b63\u898f\u5316\u3055\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u306e\u30d7\u30e9\u30a4\u30de\u30fc\u3092\u4f7f\u7528\u3057\u305f\uff1a<em>Gapdh<\/em>\u30015&#8242;-CCTCGTCCCGTAGACAAAATG-3 &#8216;\u304a\u3088\u30735&#8217;-TCTCCACTTTGCCACTGCAA-3&#8217;\u3002<em>Il7r<\/em>\u30015&#8242;-GGATGGAGACCTAGAAGATG-3 &#8216;\u304a\u3088\u30735&#8242;-GAGTTAGGCATTTCACTCGT-3&#8217;;&nbsp;<em>Cxcr4\u30015&#8242;<\/em>&nbsp;-TGTTGCCATGGAACCGATCA-3 &#8216;\u304a\u3088\u30735&#8242;-TGGTGGGCAGGAAGATCCTA-3&#8217;;&nbsp;<em>BCL2<\/em>\u30015&#8242;-TCGCTACCGTCGTGACTTC-3 &#8216;\u304a\u3088\u30735&#8242;-AAACAGAGGTCGCATGCTG-3&#8217;;&nbsp;<em>Bclxl<\/em>\u30015&#8242;-GGAGAGCGTTCAGTGATC-3 &#8216;\u304a\u3088\u30735&#8242;-CAATGGTGGCTGAAGAGA-3&#8217;;<em>Il4\u30015&#8242;<\/em>&nbsp;-AGGAGCCATATCCACGGATG-3 &#8216;\u304a\u3088\u30735&#8242;-ACAGACGAGCTCACTCTCTG-3&#8217;;&nbsp;<em>Il13\u30015&#8242;<\/em>&nbsp;-CAGCTCCCTGGTTCTCTCAC-3 &#8216;\u304a\u3088\u30735&#8217;-ACACTCCATACCATGCTGCC-3&#8217;\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30af\u30ed\u30de\u30c1\u30f3\u514d\u75ab\u6c88\u964d\u30a2\u30c3\u30bb\u30a4\uff08ChIP\uff09<\/h4>\n\n\n\n<p>ChIP\u306f\u524d\u8ff0\u306e\u3088\u3046\u306b\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib29\">Lee et al\u3002\u30012005<\/a>\uff09\u3002\u7c21\u5358\u306b\u8aac\u660e\u3059\u308b\u3068\u30015\u00d7&nbsp;106<sup>\u500b\u306e<\/sup>\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u30921\uff05\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u3067\u3001\u5ba4\u6e29\u30675\u5206\u9593\u56fa\u5b9a\u3057\u307e\u3057\u305f\u3002\u53ef\u6eb6\u6027\u30af\u30ed\u30de\u30c1\u30f3\u30925\u03bcg\u306e\u6297GR\u6297\u4f53\uff08BuGR-2\u3001Merck\uff09\u307e\u305f\u306f\u30de\u30a6\u30b9IgG\uff08Jackson ImmunoResearch\uff09\u3067\u4e00\u6669\u514d\u75ab\u6c88\u964d\u3055\u305b\u307e\u3057\u305f\u3002\u7cbe\u88fd\u3055\u308c\u305fChIP\u3068\u5165\u529bDNA\u306f\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002CNS-1\u9818\u57df\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u305fPCR\u30d7\u30e9\u30a4\u30de\u30fc\u306fCNS-1 \/ F\u30015&#8242;-CCATTGCTCACCCACAATCTC-3 &#8216;\u3067\u3057\u305f\u3002CNS-1 \/ R\u30015&#8217;-GCTATCACTCCATGGTGAAC-3 &#8216;\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30c8\u30e9\u30f3\u30b9\u30a6\u30a7\u30eb\u904a\u8d70\u30a2\u30c3\u30bb\u30a4<\/h4>\n\n\n\n<p>\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092\u7121\u8840\u6e05\u57f9\u5730\uff081\uff05BSA\u300110 mM HEPES [pH7.4]\u3092\u542b\u3080RPMI1640\uff09\u306b\u61f8\u6fc1\u3057\u307e\u3057\u305f\u3002\u79fb\u52d5\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u5b54\u5f845\u03bcm\u306e\u30dd\u30ea\u30ab\u30fc\u30dc\u30cd\u30fc\u30c8\u30e1\u30f3\u30d6\u30ec\u30f3\u3092\u5099\u3048\u305f\u30c8\u30e9\u30f3\u30b9\u30a6\u30a7\u30eb\u30c1\u30e3\u30f3\u30d0\u30fc\u3067\u5b9f\u65bd\u3057\u307e\u3057\u305f\uff08Corning\uff09\u3002100 ng \/ ml\u306eCXCL12\uff08TONBO\uff09\u3092\u542b\u3080\u57f9\u5730\u3092\u4e0b\u90e8\u30c1\u30e3\u30f3\u30d0\u30fc\u306b\u52a0\u3048\u3001\u30e1\u30f3\u30d6\u30ec\u30f3\u3092\u4e0a\u90e8\u306b\u914d\u7f6e\u3057\u307e\u3057\u305f\u3002T\u7d30\u80de\uff081\u00d710&nbsp;<sup>5<\/sup>\uff09\u3092\u4e0a\u90e8\u30c1\u30e3\u30f3\u30d0\u30fc\u306b\u30ed\u30fc\u30c9\u3057\u300137\u2103\u30672\u6642\u9593\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u4e0b\u90e8\u30c1\u30e3\u30f3\u30d0\u30fc\u5185\u306e\u7d30\u80de\u3092\u53ce\u96c6\u3057\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u5206\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;<em>\u30a4\u30f3\u30d3\u30dc<\/em>\u30db\u30fc\u30df\u30f3\u30b0\u30a2\u30c3\u30bb\u30a4<\/h4>\n\n\n\n<p>\u30de\u30a6\u30b9\u306f\u3001\u30ca\u30a4\u30fc\u30d6CD4 ZT4\u53c8\u306fZT16\u3067\u5c60\u6bba\u3057\u3001\u305d\u3057\u3066\u7cbe\u88fd\u3057\u305f<sup>+<\/sup>\u5236\u5fa1CD45.1\u304b\u3089T\u7d30\u80de\u3092<sup>+<\/sup>\uff08C57BL \/ 6\uff09\u53ca\u3073CD45.2&nbsp;<sup>+<\/sup>\uff08<em>Nr3c1&nbsp;<\/em><sup>FL \/ FL&nbsp;<\/sup><em>CD4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u53c8\u306f<em>IL7R&nbsp;<\/em><sup>CNS1.GRE12m \/ 12\u30e1\u30fc\u30c8\u30eb<\/sup>\uff09\u30de\u30a6\u30b9\u30921\uff1a1\u306e\u6bd4\u7387\u3067\u6df7\u5408\u3057\u3001CFSE\u3067\u6a19\u8b58\u3057\u3001CD45.2&nbsp;<sup>+<\/sup>&nbsp;C57BL \/ 6\u30de\u30a6\u30b9\uff08\u5408\u8a085\u00d710&nbsp;<sup>6<\/sup>\uff09\u306b\u305d\u308c\u305e\u308cZT6\u307e\u305f\u306fZT18\u3067\u79fb\u3057\u307e\u3057\u305f\u3002\u30c9\u30ca\u30fc\u7d30\u80de\u306e\u6b63\u78ba\u306a\u79fb\u5165\u524d\u306e\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u306f\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u3063\u3066\u6b8b\u308a\u306e\u30c9\u30ca\u30fc\u7d30\u80de\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u305f\u3002CFSE&nbsp;<sup>+<\/sup>\u30c9\u30ca\u30fc\u7d30\u80de\u306f\u3001\u813e\u81d3\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u304a\u3088\u3073\u672b\u68a2\u8840\u30671\u6642\u9593\u5f8c\u306b\u5206\u6790\u3055\u308c\u307e\u3057\u305f\u3002CD45.1&nbsp;<sup>+<\/sup>\u304b\u3089\u306e\u30c9\u30ca\u30fc\u7d30\u80de\u306e\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8<sup><\/sup>\u793a\u3055\u308c\u305f\u7d44\u7e54\u306e\u7dcfCFSE&nbsp;<sup>+<\/sup>\u30c9\u30ca\u30fc\u7d30\u80de\u306b\u304a\u3051\u308b\u5bfe\u7167\u30de\u30a6\u30b9\u304a\u3088\u3073CD45.2&nbsp;<sup>+<\/sup>\u5909\u7570\u4f53\uff08<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\u307e\u305f\u306f<em>Il7rCNS1.GRE12m&nbsp;<\/em><sup>\/ 12 m<\/sup>\uff09\u30de\u30a6\u30b9\u306f\u3001\u30c9\u30ca\u30fc\u7d30\u80de\u306e\u79fb\u690d\u524d\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u306b\u3088\u3063\u3066\u6b63\u898f\u5316\u3055\u308c\u305f\u3002<sup><\/sup><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u514d\u75ab\u7d44\u7e54\u5316\u5b66<\/h4>\n\n\n\n<p>\u30de\u30a6\u30b9\u3092ZT16\u3067\u72a0\u7272\u306b\u3057\u3001\u30ea\u30f3\u30d1\u7bc0\u304b\u3089\u7cbe\u88fd\u3057\u305fT\u7d30\u80de\u3092CMTMR\uff08Setareh Biotech\uff09\u307e\u305f\u306fCellTracker Deep Red\uff08Thermo Fisher Scientific\uff09\u3067\u6a19\u8b58\u3057\u3001ZT18\u3067<em>Cxcl12<\/em>&nbsp;-GFP\u304a\u3088\u3073<em>Il7<\/em>&nbsp;-GFP\u30de\u30a6\u30b9\u306b\u79fb\u3057\u307e\u3057\u305f\u3002\uff11\u6642\u9593\u5f8c\u3001\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u30de\u30a6\u30b9\u306e\u813e\u81d3\u3092\uff14\uff05\u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u3067\uff16\u6642\u9593\u56fa\u5b9a\u3057\u305f\u3002\u7d44\u7e54\u5207\u7247\u306f\u3001\u4ee5\u524d\u306b\u8a18\u8f09\u3055\u308c\u305f\u3088\u3046\u306b\u8abf\u88fd\u304a\u3088\u3073\u5206\u6790\u3055\u308c\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib6\">Cui et al\u3002\u30012014<\/a>\uff09\u3002\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u5f8c\u3001\u30b5\u30f3\u30d7\u30eb\u3092\u6297TCR\u03b2\uff08H57-597\uff09\u3001\u6297B220\uff08RA3-6B2\uff09\u3001\u6297CD31\uff08MEC13.3\uff09\u3001\u6297\u30a6\u30b5\u30aeIgG\uff08Poly4064\uff09\u3001\u6297GFP\u30a6\u30b5\u30ae\u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3001\u304a\u3088\u3073streptavidin\u2013Brilliant Violet 421\u3092\u4f7f\u7528\u3057\u3066\u3001T\u7d30\u80de\u30be\u30fc\u30f3\u3001B\u7d30\u80de\u30be\u30fc\u30f3\u3001\u304a\u3088\u3073IL-7\u30b7\u30b0\u30ca\u30eb\u3092\u691c\u51fa\u3057\u3001PermaFluor\u5c01\u5165\u5264\uff08Shandon\uff09\u3067\u5c01\u5165\u3057\u307e\u3059\u3002\u5171\u7126\u70b9\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306f\u200b\u200b\u3001TSC-SP8\u9855\u5fae\u93e1\uff08LeicaMicrosystems\uff09\u3067\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u6295\u4e0e<\/h4>\n\n\n\n<p>\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f321-\u30ea\u30f3\u9178\u4e8c\u30ca\u30c8\u30ea\u30a6\u30e0\u5869\uff08200\u03bcg\uff09\uff08Sigma\uff09\u307e\u305f\u306fPBS\u3092ZT0\u3067\u8179\u8154\u5185\u6ce8\u5c04\u3057\u305f\u30024\u6642\u9593\u5f8c\uff08ZT4\uff09\u3001\u30de\u30a6\u30b9\u3092\u72a0\u7272\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30ab\u30b9\u30d1\u30fc\u30bc\u30a2\u30c3\u30bb\u30a4<\/h4>\n\n\n\n<p>\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092ZT4\u307e\u305f\u306fZT16\u3067\u7cbe\u88fd\u3057\u3001IL-7\u3092\u542b\u307e\u306a\u3044\u57f9\u5730\u30673\u6642\u9593\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u6d3b\u6027\u30ab\u30b9\u30d1\u30fc\u30bc-3\u306e\u767a\u73fe\u306f\u3001CaspGLOW\u30d5\u30eb\u30aa\u30ec\u30bb\u30a4\u30f3\u6d3b\u6027\u30ab\u30b9\u30d1\u30fc\u30bc-3\u67d3\u8272\u30ad\u30c3\u30c8\uff08Thermo Fisher Scientific\uff09\u3092\u4f7f\u7528\u3057\u3066\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u514d\u75ab<\/h4>\n\n\n\n<p>ZT16\u3067\u30df\u30e7\u30a6\u30d0\u30f3\uff08Thermo Scientific\uff09\u306b\u4e73\u5316\u3057\u305f100\u03bcg\u306eOVA\uff08\u30b0\u30ec\u30fc\u30c9V\u3001Sigma Aldrich\uff09\u3092\u8179\u8154\u5185\u6ce8\u5c04\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30de\u30a6\u30b9\u3092\u514d\u75ab\u3057\u307e\u3057\u305f\u3002\u813e\u7d30\u80de\u30927\u65e5\u5f8c\u306b\u5358\u96e2\u3057\u3001100\u03bcg\/ mlOVA\u306772\u6642\u9593\u523a\u6fc0\u3057\u305f\u3002\u523a\u6fc0\u5f8c\u3001\u57f9\u990a\u4e0a\u6e05\u4e2d\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092ELISA\uff08eBioscience\uff09\u3067\u6e2c\u5b9a\u3057\u305f\u3002Tfh\u7d30\u80de\uff08TCR\u03b2&nbsp;<sup>+<\/sup>&nbsp;CD4&nbsp;<sup>+<\/sup>&nbsp;CD44&nbsp;<sup>+<\/sup>&nbsp;CXCR5&nbsp;<sup>+<\/sup>&nbsp;PD-1&nbsp;<sup>+<\/sup>\uff09\u3092\u30bd\u30fc\u30c8\u3057\u3001\u305d\u308c\u3089\u306emRNA\u3092\u7cbe\u88fd\u3057\u307e\u3057\u305f\u3002\u80da\u4e2d\u5fc3B\u7d30\u80de\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306b\u3001ZT4\u307e\u305f\u306fZT16\u306e\u30df\u30e7\u30a6\u30d0\u30f3\u306b\u4e73\u5316\u3057\u305f100\u03bcg\u306eOVA\u3092\u8179\u8154\u5185\u6ce8\u5c04\u3057\u3066\u30de\u30a6\u30b9\u3092\u514d\u75ab\u3057\u307e\u3057\u305f\u300212\u65e5\u5f8c\u3001\u813e\u81d3\u7d30\u80de\u3092\u6297\u4f53\u3067\u67d3\u8272\u3057\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u6297\u4f53\u7523\u751f\u306e\u305f\u3081\u306b\u3001ZT16\u3067\u30df\u30e7\u30a6\u30d0\u30f3\u306b\u4e73\u5316\u3055\u308c\u305f100\u03bcg\u306eNP-OVA\uff08LGC Biosearch Technologies\uff09\u3092\u8179\u8154\u5185\u6ce8\u5c04\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30de\u30a6\u30b9\u3092\u514d\u75ab\u3057\u305f\u300220\u65e5\u5f8c\u3001\u8840\u6e05\u3092\u53ce\u96c6\u3057\u3001\u4ee5\u524d\u306b\u8a18\u8f09\u3055\u308c\u305f\u3088\u3046\u306bELISA\u306b\u3088\u3063\u3066\u5206\u6790\u3057\u305f\uff08<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#bib20\">\u79e6\u307b\u304b\u30012016\u5e74<\/a>\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;Th\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u8a98\u5c0e<\/h4>\n\n\n\n<p>ZT4\u304a\u3088\u3073ZT16\u3067\u5358\u96e2\u3055\u308c\u305f\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306f\u3001IL-12\u306e\u5b58\u5728\u4e0b\u30674\u03bcg\/ ml\u30d7\u30ec\u30fc\u30c8\u7d50\u5408\u6297CD3\u30014\u03bcg \/ ml\u53ef\u6eb6\u6027\u6297CD28\u3001\u304a\u3088\u307320 ng \/ ml hIL-2\u3068\u3068\u3082\u306b\u57f9\u990a\u3055\u308c\u307e\u3057\u305f\uff0810 Th1\u5206\u5316\u306b\u306fng \/ ml\uff09\u3068\u6297IL-4\u6297\u4f53\uff085 ng \/ ml\uff09\u3001Th2\u5206\u5316\u306b\u306fIL-4\uff0810 ng \/ ml\uff09\u3068\u6297IFN-\u03b3\u6297\u4f53\uff085 ng \/ ml\uff09\u30027\u65e5\u5f8c\u3001\u7d30\u80de\u3092PMA\uff0850 ng \/ ml\uff09\u304a\u3088\u3073\u30a4\u30aa\u30ce\u30de\u30a4\u30b7\u30f3\uff082\u03bcg\/ ml\uff09\u3067\u30d6\u30ec\u30d5\u30a7\u30eb\u30b8\u30f3A\u306e\u5b58\u5728\u4e0b\u30674\u6642\u9593\u518d\u523a\u6fc0\u3057\u307e\u3057\u305f\u3002\u518d\u523a\u6fc0\u5f8c\u3001\u7d30\u80de\u3092\u56fa\u5b9a\u3057\u3001\u900f\u904e\u51e6\u7406\u3057\u3001\u6307\u793a\u3055\u308c\u305f\u6297\u4f53\u3067\u67d3\u8272\u3057\u307e\u3057\u305f\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">&nbsp;\u30e1\u30e2\u30ea\u30fcCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u751f\u6210<\/h4>\n\n\n\n<p><em>Nr3c1&nbsp;<\/em><sup>fl \/ fl<\/sup>\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09\u3001<em>Nr3c1&nbsp;<\/em><sup>fl \/ fl&nbsp;<\/sup><em>Cd4<\/em>&nbsp;-cre&nbsp;<sup>+<\/sup>\uff08GRcKO\uff09\u3001\u307e\u305f\u306f<em>Il7r&nbsp;<\/em><sup>CNS1.GRE12m \/ 12 m<\/sup>\uff08GRE12m\uff09\u30de\u30a6\u30b9\u304b\u3089\u7cbe\u88fd\u3057\u305f\u30ca\u30a4\u30fc\u30d6CD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u3092\u3001Th2\u6761\u4ef6\u4e0b\u30676\u65e5\u9593\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\uff082.5\u00d710&nbsp;<sup>7<\/sup>\uff09\u3092B6.CD45.1&nbsp;<sup>+<\/sup>\u30de\u30a6\u30b9\u306b\u79fb\u3057\u307e\u3057\u305f\u30024\u9031\u9593\u5f8c\u3001\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u30de\u30a6\u30b9\u3092\u72a0\u7272\u306b\u3057\u3001\u813e\u81d3\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u304a\u3088\u3073\u80ba\u304b\u3089\u306e\u30ea\u30f3\u30d1\u7403\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u5206\u6790\u3057\u307e\u3057\u305f\u3002<em><\/em><sup><\/sup><em><\/em><sup><\/sup><em><\/em><sup><\/sup><em><\/em><sup><\/sup><sup><\/sup><sup><\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;\u5b9a\u91cf\u5316\u3068\u7d71\u8a08\u5206\u6790<\/h3>\n\n\n\n<p>\u3059\u3079\u3066\u306e\u30c7\u30fc\u30bf\u306f\u5e73\u5747\u00b1SEM\u3068\u3057\u3066\u8868\u3055\u308c\u307e\u3059\u30022\u3064\u306e\u30b5\u30f3\u30d7\u30eb\u9593\u306e\u6bd4\u8f03\u306f\u3001\u5bfe\u5fdc\u306e\u306a\u3044\u4e21\u5074\u30b9\u30c1\u30e5\u30fc\u30c7\u30f3\u30c8\u306et\u691c\u5b9a\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u5143\u914d\u7f6e\u5206\u6563\u5206\u6790\u3068\u305d\u308c\u306b\u7d9a\u304f\u30c6\u30e5\u30fc\u30ad\u30fc\u306e\u591a\u91cd\u6bd4\u8f03\u691c\u5b9a\u304a\u3088\u3073\u4e8c\u5143\u914d\u7f6e\u5206\u6563\u5206\u6790\u3092\u4f7f\u7528\u3057\u3066\u3001\u8907\u6570\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u7d71\u8a08\u5206\u6790\u306f\u3001GraphPad Prism7\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002<sup>\u2217<\/sup>&nbsp;p &lt;0.05\u3001<sup>\u2217\u2217<\/sup>&nbsp;p &lt;0.01\u3001\u304a\u3088\u3073<sup>\u2217\u2217\u2217<\/sup>&nbsp;p &lt;0.001\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0200\">\u8b1d\u8f9e<\/h2>\n\n\n\n<p>Drs\u306b\u611f\u8b1d\u3057\u307e\u3059\u3002KY1.1 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class=\"wp-block-heading\">\u8457\u8005\u306e\u8ca2\u732e<\/h3>\n\n\n\n<p>AS\u306f\u5b9f\u9a13\u3092\u8a2d\u8a08\u304a\u3088\u3073\u5b9f\u884c\u3057\u3001\u8ad6\u6587\u3092\u57f7\u7b46\u3057\u307e\u3057\u305f\u3002GC\u3001ST\u3001MO\u3001SA\u3001FO\u3001\u304a\u3088\u3073TH\u306f\u3044\u304f\u3064\u304b\u306e\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002SK\u3068HM\u306fGRE\u5909\u7570\u30de\u30a6\u30b9\u3092\u751f\u6210\u3057\u307e\u3057\u305f\u3002HY\u3068YY\u306fLM-OVA\u3092\u63d0\u4f9b\u3057\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3092\u76e3\u7763\u3057\u307e\u3057\u305f\u3002TN\u306f<em>Cxcr4fl&nbsp;<\/em><sup>\/ fl<\/sup>\u304a\u3088\u3073<em>Cxcl12<\/em>&nbsp;-GFP\u30de\u30a6\u30b9\u3092\u63d0\u4f9b\u3057<em>\u307e\u3057<\/em>\u305f\u3002GS\u306f<em>Nr3c1fl&nbsp;<\/em><sup>\/ fl<\/sup>\u30de\u30a6\u30b9\u3092\u63d0\u4f9b\u3057<em>\u307e\u3057<\/em>\u305f\u3002KI\u306f\u3001\u7814\u7a76\u306e\u6982\u5ff5\u5316\u3068\u76e3\u7763\u3001\u3044\u304f\u3064\u304b\u306e\u5b9f\u9a13\u306e\u8a2d\u8a08\u3068\u5b9f\u884c\u3001\u30c7\u30fc\u30bf\u306e\u8b70\u8ad6\u3001\u8ad6\u6587\u306e\u57f7\u7b46\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5229\u5bb3\u95a2\u4fc2\u306e\u5ba3\u8a00<\/h3>\n\n\n\n<p>\u8457\u8005\u306f\u3001\u5ba3\u8a00\u3059\u308b\u305f\u3081\u306e\u7af6\u5408\u3059\u308b\u5229\u5bb3\u95a2\u4fc2\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"supplementaryMaterial\">\u88dc\u8db3\u60c5\u5831<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.cell.com\/cms\/10.1016\/j.immuni.2018.01.004\/attachment\/4407e11c-abda-4804-829a-6979eca35b70\/mmc1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">.pdf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\uff082.23 MB\uff09<\/a><a href=\"https:\/\/service.elsevier.com\/app\/answers\/detail\/a_id\/19286\/supporthub\/sciencedirect\/\" target=\"_blank\" rel=\"noreferrer noopener\">PDF\u30d5\u30a1\u30a4\u30eb\u306e\u30d8\u30eb\u30d7<\/a>\u30c9\u30ad\u30e5\u30e1\u30f3\u30c8S1\u3002\u56f3S1\u301cS7<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secsectitle0225\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ol class=\"wp-block-list\"><li><ul><li>\u963f\u90e8A\u3002<\/li><li>\u8c37\u4e00S.<\/li><li>\u30b7\u30bf\u30e9S\u3002<\/li><li>CuiG\u3002<\/li><li>\u5c71\u7530\u79c0\u6a39<\/li><li>\u30df\u30e4\u30c1H.<\/li><li>\u5317\u91ceS.<\/li><li>\u539fT\u3002<\/li><li>\u963f\u90e8R\u3002<\/li><li>\u5409\u6d77Y.<\/li><li>\u751f\u7530K.<\/li><\/ul>IL-7\u53d7\u5bb9\u4f53\u03b1\u9396\u907a\u4f1d\u5b50\u5ea7\u306e\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u306f\u3001IL-7\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3068\u672b\u68a2T\u7d30\u80de\u306e\u7dad\u6301\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<em>J.Immunol\u3002<\/em>&nbsp;2015;&nbsp;<strong>195<\/strong>\uff1a&nbsp;3129-3138<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#back-bib1\">\u8a18\u4e8b\u3067\u898b\u308b&nbsp;<\/a><ul><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_1_2&amp;dbid=137438953472&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=2-s2.0-84942436430&amp;cf=\">Scopus\uff089\uff09<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_1_2&amp;dbid=8&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=26336149&amp;cf=\">PubMed<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_1_2&amp;dbid=16&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=10.4049%2Fjimmunol.1302447&amp;cf=\">Crossref<\/a><\/li><li><a 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href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#back-bib45\">\u8a18\u4e8b\u3067\u898b\u308b&nbsp;<\/a><ul><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_45_2&amp;dbid=137438953472&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=2-s2.0-14844364003&amp;cf=\">Scopus\uff0836\uff09<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_45_2&amp;dbid=8&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=15749896&amp;cf=\">PubMed<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/servlet\/linkout?suffix=e_1_5_1_2_45_2&amp;dbid=16&amp;doi=10.1016\/j.immuni.2018.01.004&amp;key=10.4049%2Fjimmunol.174.6.3590&amp;cf=\">Crossref<\/a><\/li><li><a href=\"http:\/\/scholar.google.com\/scholar_lookup?hl=en&amp;volume=174&amp;publication_year=2005&amp;pages=3590-3597&amp;journal=J.%C2%A0Immunol.&amp;author=Yajima+T.&amp;author=Nishimura+H.&amp;author=Sad+S.&amp;author=Shen+H.&amp;author=Kuwano+H.&amp;author=Yoshikai+Y.&amp;title=A+novel+role+of+IL-15+in+early+activation+of+memory+CD8%2B+CTL+after+reinfection\">Google Scholar<\/a><\/li><\/ul><\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"articleInformation\">\u8a18\u4e8b\u60c5\u5831<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u51fa\u7248\u5c65\u6b74<\/h3>\n\n\n\n<p>\u516c\u958b\u65e5\uff1a2018\u5e741\u670823\u65e5\u627f\u8a8d\u6e08\u307f\uff1a2017\u5e7412\u670829\u65e5\u6539\u8a02\u7248\u3067\u53d7\u9818\uff1a2017\u5e749\u67085\u65e5\u53d7\u9818\u65e5\uff1a2017\u5e743\u67082\u65e5<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8b58\u5225<\/h3>\n\n\n\n<p>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.immuni.2018.01.004\">https<\/a>\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.immuni.2018.01.004\">\/\/doi.org\/10.1016\/j.immuni.2018.01.004<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8457\u4f5c\u6a29<\/h3>\n\n\n\n<p>\u00a92018Elsevier Inc.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30e6\u30fc\u30b6\u30fc\u30e9\u30a4\u30bb\u30f3\u30b9<\/h3>\n\n\n\n<p><a href=\"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/\">\u30a8\u30eb\u30bc\u30d3\u30a2\u306e\u30e6\u30fc\u30b6\u30fc\u30e9\u30a4\u30bb\u30f3\u30b9<\/a>|&nbsp;<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u518d\u5229\u7528\u3059\u308b\u65b9\u6cd5<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.cell.com\/templates\/jsp\/_style2\/_marlin\/images\/information.png?w=640&#038;ssl=1\" alt=\"\u60c5\u5831\u30a2\u30a4\u30b3\u30f3\" data-recalc-dims=\"1\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">ScienceDirect<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074761318300049\">ScienceDirect\u3067\u3053\u306e\u8a18\u4e8b\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"figures\">\u6570\u5b57<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>\u30b0\u30e9\u30d5\u30a3\u30ab\u30eb\u306a\u62bd\u8c61<\/strong><\/li><li><strong>\u56f3<\/strong>1GR\u306fIL-7R\u306e\u767a\u73fe\u3068T\u7d30\u80de\u306e\u5206\u5e03\u3092\u65e5\u4e2d\u5236\u5fa1\u3059\u308b<\/li><li><strong>\u56f3<\/strong>2GR\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u306f\u3001T\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/li><li><strong>\u56f3<\/strong>3GR\u306b\u3088\u308bIL-7R\u8a98\u5c0e\u306f\u3001CXCR4\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308aT\u7d30\u80de\u5206\u5e03\u306e\u65e5\u5909\u5316\u3092\u5236\u5fa1\u3057\u307e\u3059<\/li><li><strong>\u56f3<\/strong>4GR\u306b\u3088\u308bCXCR4\u767a\u73fe\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306fCXCL12\u7523\u751f\u7d30\u80de\u3078\u306eT\u7d30\u80de\u904a\u8d70\u3092\u8a98\u5c0e\u3059\u308b<\/li><li><strong>\u56f3<\/strong>5GR\u306fT\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u5897\u6b96\u3068\u514d\u75ab\u5fdc\u7b54\u306e\u65e5\u5909\u5316\u3092\u8abf\u7bc0\u3059\u308b<\/li><li><strong>\u56f3<\/strong>6GR\u306fTh\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u5316\u3068\u4f53\u6db2\u6027\u514d\u75ab\u53cd\u5fdc\u3092\u5236\u5fa1\u3057\u307e\u3059<\/li><li><strong>\u56f3<\/strong>7GR\u306f\u3001IL-7R\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30e1\u30e2\u30ea\u30fcCD4&nbsp;<sup>+<\/sup>&nbsp;T\u7d30\u80de\u306e\u7dad\u6301\u3092\u30b5\u30dd\u30fc\u30c8\u3057<strong>\u307e\u3059<\/strong><sup><\/sup><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"relatedArticles\">\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)30162-8\">\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u3078\u306e\u5468\u7523\u671f\u66dd\u9732\u306b\u3088\u308bCD8T\u7d30\u80de\u514d\u75ab\u306e\u9577\u671f\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0<\/a>Hong etal\u3002<em>\u30bb\u30eb<\/em>2020\u5e743\u67085\u65e5<ul><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u7c21\u5358\u306b\u8a00\u3048\u3070<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)30162-8\">\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/pdf\/S0092-8674(20)30162-8.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li><\/ul><\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(20)30358-7\">\u5185\u56e0\u6027\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001CD8 + T\u7d30\u80de\u306e\u5206\u5316\u3068\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u304a\u3051\u308b\u6a5f\u80fd\u969c\u5bb3\u306e\u767a\u75c7\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/a>Acharya etal\u3002<em>\u30a4\u30df\u30e5\u30cb\u30c6\u30a3<\/em>2020\u5e749\u670815\u65e5<ul><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u7c21\u5358\u306b\u8a00\u3048\u3070<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(20)30358-7\">\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/pdf\/S1074-7613(20)30358-7.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li><\/ul><\/li><li><a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(18)30532-4\">\u6025\u6027\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u8010\u6027\uff1aBIM\u304c\u3064\u3044\u306b<\/a>\u30d6\u30e9\u30a6\u30f3\u7b49\u3002<em>\u304c\u3093\u7d30\u80de<\/em>2018\u5e7412\u670810\u65e5<ul><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u7c21\u5358\u306b\u8a00\u3048\u3070<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(18)30532-4\">\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cancer-cell\/pdf\/S1535-6108(18)30532-4.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li><\/ul>\u30a2\u30fc\u30ab\u30a4\u30d6\u3092\u958b\u304f<\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)01425-6\">\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u3092\u56de\u907f\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6297\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u4ed8\u4e0e\u3057\u307e\u3059<\/a>\u30a2\u30ed\u30e9\u4ed6<em>\u30bb\u30eb<\/em>2013\u5e7412\u67085\u65e5<ul><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u7c21\u5358\u306b\u8a00\u3048\u3070<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)01425-6\">\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/pdf\/S0092-8674(13)01425-6.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li><\/ul>\u30a2\u30fc\u30ab\u30a4\u30d6\u3092\u958b\u304f<\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(20)30282-X\">\u7cd6\u8cea\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u6297\u708e\u75c7\u4f5c\u7528\u306f\u3001miR-342\u4f9d\u5b58\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u3066Foxp3 +\u5236\u5fa1\u6027T\u7d30\u80de\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u307e\u3059<\/a>\u30ad\u30e0\u3089<em>\u30a4\u30df\u30e5\u30cb\u30c6\u30a3<\/em>2020\u5e747\u670823\u65e5<ul><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(18)30004-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318300049%3Fshowall%3Dtrue#\">\u7c21\u5358\u306b\u8a00\u3048\u3070<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(20)30282-X\">\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/immunity\/pdf\/S1074-7613(20)30282-X.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"comments-heading\">\u30b3\u30e1\u30f3\u30c8<\/h2>\n\n\n\n<figure><iframe width=\"100%\" src=\"https:\/\/disqus.com\/embed\/comments\/?base=default&amp;f=cell-press&amp;t_i=10.1016%2Fj.immuni.2018.01.004&amp;t_u=http%3A%2F%2Fwww.cell.com%2Fretrieve%2Fpii%2FS1074-7613(18)30004-9&amp;t_e=Glucocorticoids%20Drive%20Diurnal%20Oscillations%20in%20T%20Cell%20Distribution%20and%20Responses%20by%20Inducing%20Interleukin-7%20Receptor%20and%20CXCR4%3A%20Immunity&amp;t_d=Glucocorticoids%20Drive%20Diurnal%20Oscillations%20in%20T%20Cell%20Distribution%20and%20Responses%20by%20Inducing%20Interleukin-7%20Receptor%20and%20CXCR4&amp;t_t=Glucocorticoids%20Drive%20Diurnal%20Oscillations%20in%20T%20Cell%20Distribution%20and%20Responses%20by%20Inducing%20Interleukin-7%20Receptor%20and%20CXCR4%3A%20Immunity&amp;s_o=default#version=d716a1690aa4a08a02a6dcd8b6774c08\"><\/iframe><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">CellPress\u306e\u30b3\u30e1\u30f3\u30c8\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/h4>\n\n\n\n<p>\u30b8\u30e3\u30fc\u30ca\u30eb\u8a18\u4e8b\u3078\u306e\u30b3\u30e1\u30f3\u30c8\u3092\u9001\u4fe1\u3059\u308b\u306b\u306f\u3001\u4e0a\u306e\u30b9\u30da\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3066\u3001\u6b21\u306e\u70b9\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<ul 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